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Chemical Structure : ONX0801
Catalog No.: PC-49048Not For Human Use, Lab Use Only.
ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC).
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ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC).
| M.Wt | 647.641 | |
| Formula | C32H33N5O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tochowicz A, et al. J Med Chem. 2013 Jul 11;56(13):5446-55.
2. Gibbs DD, et al. Cancer Res. 2005 Dec 15;65(24):11721-8.
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