| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-38124 |
NSC194598
|
5358-76-9 |
NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50=180 nM) and in vivo. |
| PC-42959 |
AMG 232
|
1352066-68-2 |
Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM. |
| PC-61494 |
COTI-2
|
1039455-84-9 |
COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway. |
| PC-61324 |
HL001
|
1186371-31-2 |
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression. |
| PC-60302 |
DS-3032b
|
1398568-47-2 |
DS-3032b is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity. |
| PC-60218 |
CB-002
|
61034-15-9 |
CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts. |
| PC-70003 |
HDM-201
|
1448867-41-1 |
HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM. |
