Catalog No.: PC-25429Not For Human Use, Lab Use Only.
Idasanutlin (RG7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM in HTRF binding assays, inhibits wt-p53 cancer cell lines (SJSA1, RKO, HCT116) with mean IC50 of 0.03 uM.
Idasanutlin (RG7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM in HTRF binding assays, inhibits wt-p53 cancer cell lines (SJSA1, RKO, HCT116) with mean IC50 of 0.03 uM. Idasanutlin (RG7388) shows >300-fold selective over mutant p53 cell lines (SW480, MDA-MB435). Idasanutlin (RG7388) effectively activated the p53 pathway in SJSA1 cells and induced tumor growth inhibition (TGI) in correlative xenografts in nude mice . Idasanutlin (RG7388) has demonstrated the ability to activate apoptosis and induce tumor stasis with continuous treatment.
