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Multikinase inhibitor 108600

Multikinase inhibitor 108600 (108600) is a novel multi-kinase inhibitor and inhibitor of TNBC growth (GI50=0.12-0.75 uM), inhibits CK2α1/α2, DYRK1A, 1B, and DYRK2 and TNIK (IC50=5-50 nM).

CK2 inhibitor KN2

CK2 inhibitor KN2 is a potent, highly selective, cell-permeable, bivalent CK2 inhibitor, binds to CK2α- and CK2α′-based CK2 holoenzymes with Ki of 6.1 nM (CK2α2β2) and 4.0 nM (CK2α′2β2).


CAM4712 (CAM-4712) is a potent and selective CK2alpha (CK2α) inhibitor with IC50 of 7 uM, exhibits cell growth inhibition in HCT116 cell line with IC50 of 10 uM.


CAM4066 (CAM-4066) is a potent and selective CK2alpha (CK2α) inhibitor with Kd of 0.32 uM and IC50 of 0.37 uM, shows significantly improved selectivity compared to other CK2α inhibitors.

(R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.


Bischof-5 (CK1δ inhibitor 5) is a potent, specific casein kinase 1δ (CK1δ) inhibitor with IC50 of 40 nM.


SR-2890 is a potent, highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 of 4 nM for CK1δ.

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