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CK2 inhibitor KN2

Chemical Structure : CK2 inhibitor KN2

CAS No.: 2938991-22-9

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CK2 inhibitor KN2 (KN2)

Catalog No.: PC-72228Not For Human Use, Lab Use Only.

CK2 inhibitor KN2 is a potent, highly selective, cell-permeable, bivalent CK2 inhibitor, binds to CK2α- and CK2α′-based CK2 holoenzymes with Ki of 6.1 nM (CK2α2β2) and 4.0 nM (CK2α′2β2).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CK2 inhibitor KN2 is a potent, highly selective, cell-permeable, bivalent CK2 inhibitor, binds to CK2α- and CK2α′-based CK2 holoenzymes with Ki of 6.1 nM (CK2α2β2) and 4.0 nM (CK2α′2β2).
    KN2 inhibits CK2α- and CK2α′-based CK2 holoenzymes with IC50 of 19.3 nM (CK2α2β2) and 15.6 nM (CK2α′2β2) at 100 uM ATP.
    KN2 downregulated the CK2-dependent phosphorylation level of Akt phosphorylation at Ser129 (p-Akt S129).

    Physicochemical Properties

    M.Wt 776.971
    Formula C23H22Br4Cl2N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(3,4-dichlorophenethyl)-N4-(4-(4,5,6,7-tetrabromo-1H-benzo[d]imidazol-1-yl)butyl)succinamide

    References

    1. Dirk Lindenblatt, et al. J Med Chem. 2022 Jan 27;65(2):1302-1312.

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