CMV compound (inhibitors, antagonists)-ProbeChem.com

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Cytomegalovirus (CMV) is a betaherpesvirus with a 50 to 90% prevalence frequency in the adult human population. It is an opportunistic pathogen controlled largely by the immune system, especially cell-mediated immunity. Clinically serious disease occurs primarily in three situations involving deficient immune systems.

Treatment of HCMV disease is limited to relatively toxic drugs with that target viral DNA synthesis. The most commonly used HCMV drug, ganciclovir, is a nucleoside prodrug phosphorylated by the viral UL97 kinase to the nucleotide analog form and is selectively incorporated into progeny DNA by the HCMV UL54-encoded DNA polymerase. Foscarnet is a pyrophosphate analog. Effective concentrations of foscarnet are much higher than that of ganciclovir. Both of these drugs are nephrotoxic; ganciclovir also causes neutropenia and is teratogenic. Cidofovir is a nucleoside phosphonate that is severely renal toxic.

Cat. No.	Product Name	CAS No.	Information
PC-35123	CFI02	273735-28-7	CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169.
PC-61945	Tomeglovir	233254-24-5	Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication.
PC-49840	NPP-669	2407828-99-1	NPP-669 (NPP669) is an orally bioavailable cidofovir (CDV) analogue and prodrug, has increased lipophilicity, improved oral absorption, reduced nephrotoxicity, increased cellular uptake, and increased activity against several dsDNA viruses compared to CDV.
PC-47051	JMX0493	1096316-34-5	JMX0493 is a potent inhibitor of human adenoviruse (HAdV) infection with IC50 of 0.78 uM (HAdV-5), targets HAdV entry pathway and prevents viral particle disassembly and subsequent release from the endosome.
PC-38784	Maribavir	176161-24-3	Maribavir (1263W94, Benzimidavir) is a potent and selective inhibitor of human cytomegalovirus (HCMV) replication with IC50 of 0.13 uM against laboratory strain AD169, and 0.03-0.13 uM against 10 clinical HCMV isolates.
PC-38414	HHV protease inhibitor 43		HHV protease inhibitor 43 is an irreversible small molecule inhibitor of human herpesvirus (HHV) protease targeting a non-catalytic cysteine (C161) with IC50 of 4 uM (HCMV), exhibits broad-spectrum inhibition of other HHV protease homologs.
PC-73324	Letermovir	917389-32-3	Letermovir (AIC246) is a potent anti-cytomegalovirus (CMV) compound, exhibits very potent in vitro antiviral activity aginst different HCMV laboratory strains (EC50=3-5 nM), through a specific antiviral mechanism that involves the viral terminase.

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