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Letermovir

Chemical Structure : Letermovir

CAS No.: 917389-32-3

Letermovir (AIC246)

Catalog No.: PC-73324Not For Human Use, Lab Use Only.

Letermovir (AIC246) is a potent anti-cytomegalovirus (CMV) compound, exhibits very potent in vitro antiviral activity aginst different HCMV laboratory strains (EC50=3-5 nM), through a specific antiviral mechanism that involves the viral terminase.

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Biological Activity

Letermovir (AIC246) is a potent anti-cytomegalovirus (CMV) compound, exhibits very potent in vitro antiviral activity aginst different HCMV laboratory strains (EC50=3-5 nM), through a specific antiviral mechanism that involves the viral terminase.
Letermovir (AIC246) interferes with HCMV DNA cleavage/packaging via a molecular mechanism that is distinct from that of other compound classes known to target the viral terminase.
Letermovir (AIC246) exhibits excellent in vitro inhibitory activity against HCMV laboratory strains and clinical isolates, retains activity against ganciclovir-resistant viruses, is well tolerated in different cell types.
Letermovir (AIC246) exerts a potent in vivo efficacy in a mouse xenograft model.

Physicochemical Properties

M.Wt 572.561
Formula C29H28F4N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Lischka P, et al. Antimicrob Agents Chemother. 2010 Mar;54(3):1290-7.

2. Kaul DR, et al. Am J Transplant. 2011 May;11(5):1079-84.

3. Marschall M, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):1135-7.

4. Goldner T, et al. J Virol. 2011 Oct;85(20):10884-93.

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