| Cat. No. |
Product Name |
Information |
| PC-49614 |
AM-5308
Kif18A inhibitor
|
AM-5308 is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 47 nM in kinesin-8 microtubule (MT)-ATPase motor assays. |
| PC-49285 |
BTB-1
Kif18A inhibitor
|
BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins. |
| PC-73363 |
UMK57
MACK (KIF2C) agonist
|
UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin‐13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells. |
| PC-72904 |
AMG650
KIF18A inhibitor
|
AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A with IC50 of 71 nM. |
| PC-72726 |
Azo-EMD
Photoswitchable Eg5 inhibitor
|
Azo-EMD is a cell permeable, photoswitchable compound that inhibits mitotic kinesin Eg5 more potently in its light-induced cis form, used for optical control mitosis. |
| PC-35945 |
GW406108X
Kif15 inhibitor
|
GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays. |
| PC-63578 |
Kif15-IN-1
KIF15 inhibitor
|
Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation.. |
| PC-63479 |
SR31527
KIFC1 inhibitor
|
SR31527 is an allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM. |
| PC-42882 |
SB-743921
KSP inhibitor
|
SB-743921 (SB-743921) is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. |
| PC-62648 |
Kinesore
KLC2-SKIP inhibitor
|
Kinesore is a small molecule activator of kinesin-1 that inhibits KLC2-SKIP interaction with IC50 of 101 uM, Ki of 49 uM. |
| PC-62405 |
MAC1
Eg5 rescuer
|
MAC1 (Monastrol Antagonizing Compound 1) is a small molecule that can rescue spindle bipolarity in cells lacking Eg5 activity. |
| PC-62374 |
AZ82
KIFC1 inhibitor
|
AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM. |
