| Cat. No. |
Product Name |
Information |
| PC-28101 |
KIF18A inhibitor 19d
KIF18A inhibitor
|
KIF18A inhibitor 19d is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 52 nM, exhibits single-digit nanomolar antiproliferative activity in CIN-high OVCAR-3 cells (EC50=3.4 nM), induces tumor regression in the OVCAR-3 xenograft model. |
| PC-27673 |
Litronesib
Eg5 inhibitor
|
Litronesib ((R)-Litronesib, LY2523355) is a potent, selective and allosteric inhibitor of mitosis-specific kinesin Eg5 (Kif11, Kinesin Spindle Protein, KSP), inhibits microtubule (MT)-stimulated Eg5 ATPase activity with IC50 of 26 nM. |
| PC-25961 |
VLS-1488
KIF18A inhibitor
|
Orvanesib (VLS-1488, KIF18A-IN-6) is a potent, selective and orally active KIF18A inhibitor, inhibits KIF18A microtubule-dependent ATPase activity with IC50 of 16 nM. |
| PC-25729 |
ATX020
KIF18A inhibitor
|
ATX020 (ATX-020) is a potent, selective and orally efficacious KIF18A (kinesin-like protein 18A) inhibitor with IC50 of 0.11 uM and 0.16 uM for human and rat KIF18A respectively. |
| PC-23792 |
VLS-1272
KIF18A inhibitor
|
VLS-1272 is a potent, ATP non-competitive, orally bioavailable, and highly selective inhibitor of KIF18A ATPase activity with IC50 of 41 nM and 8.8 nM for human and murine KIF18A (0.1 mM ATP), respectively. |
| PC-21659 |
AM-1882
Kif18A inhibitor
|
AM-1882 (AM1882) is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 230 nM in kinesin-8 microtubule (MT)-ATPase motor assays. |
| PC-21658 |
AM-9022
Kif18A inhibitor
|
AM-9022 (AM9022) is a potent, selective and orally active mitotic kinesin KIF18A inhibitor with IC50 of 47 nM in kinesin-8 microtubule (MT)-ATPase motor assays. |
| PC-49614 |
AM-5308
Kif18A inhibitor
|
AM-5308 is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 47 nM in kinesin-8 microtubule (MT)-ATPase motor assays. |
| PC-49285 |
BTB-1
Kif18A inhibitor
|
BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins. |
| PC-73363 |
UMK57
MACK agonist
|
UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin-13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells. |
| PC-73188 |
Filanesib
KSP inhibitor
|
Filanesib (ARRY-520) is a potent, selective and noncompetitive kinesin spindle protein (KSP, KIF11) inhibitor with IC50 of 6 nM. |
| PC-72904 |
Sovilnesib
KIF18A inhibitor
|
Sovilnesib (AMG650, AMG650) is an oral, first in class, selective small molecule inhibitor of KIF18A with IC50 of 71 nM. |
