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Chemical Structure : AM-1882
Catalog No.: PC-21659Not For Human Use, Lab Use Only.
AM-1882 (AM1882) is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 230 nM in kinesin-8 microtubule (MT)-ATPase motor assays.
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AM-1882 (AM1882) is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 230 nM in kinesin-8 microtubule (MT)-ATPase motor assays.
AM-1882 exhibits good specificity against a panel of diverse kinesin motor proteins, except for the KIF19A motor (IC50=1820 nM).
AM-1882 shows cellular EC50 of 21 and 15 nM for cell line pH3+ and PCM foci in mitotic image assays respectively.
AM-1882 has similar inhibitory effects on the motor activity of human and mouse KIF18A.
AM-1882 is active in a subset of cancer cell lines with CCNE1, BRCA1 and RB1 gene alterations and can enhance apoptosis when combined with PARP inhibition.
AM-1882 (50 or 100 mg per kg, i.p.) inhibited tumor growth in OVCAR-8 CDX tumor model.
| M.Wt | 576.77 | |
| Formula | C28H40N4O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marc Payton, et al. Nat Cancer. 2023 Dec 27. doi: 10.1038/s43018-023-00699-5.
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