Chemical Structure : AM-1882
CAS No.:
2600559-12-2
AM-1882
(AM1882)
Catalog No.: PC-21659Not For Human Use, Lab Use Only.
AM-1882 (AM1882) is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 230 nM in kinesin-8 microtubule (MT)-ATPase motor assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AM-1882 (AM1882) is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 230 nM in kinesin-8 microtubule (MT)-ATPase motor assays.
AM-1882 exhibits good specificity against a panel of diverse kinesin motor proteins, except for the KIF19A motor (IC50=1820 nM).
AM-1882 shows cellular EC50 of 21 and 15 nM for cell line pH3+ and PCM foci in mitotic image assays respectively.
AM-1882 has similar inhibitory effects on the motor activity of human and mouse KIF18A.
AM-1882 is active in a subset of cancer cell lines with CCNE1, BRCA1 and RB1 gene alterations and can enhance apoptosis when combined with PARP inhibition.
AM-1882 (50 or 100 mg per kg, i.p.) inhibited tumor growth in OVCAR-8 CDX tumor model.
Physicochemical Properties
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M.Wt
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576.77
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Formula
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C28H40N4O5S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(N-(tert-butyl)sulfamoyl)-N-(3-(N-(tert-butyl)sulfamoyl)phenyl)-2-(6-azaspiro[2.5]octan-6-yl)benzamide
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References
1. Marc Payton, et al. Nat Cancer. 2023 Dec 27. doi: 10.1038/s43018-023-00699-5.
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