| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-43493 |
CX-5461
|
1138549-36-6 |
Pidnarulex (CX-5461) is the first potent, selective, orally bioavailable inhibitor of RNA polymerase I, selectively inhibits rRNA synthesis in HCT-116 cells with IC50 of 142 nM, 200-fold selectivity over Pol II. |
| PC-62219 |
CX-3543
|
865311-47-3 |
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells. |
| PC-61350 |
Mithramycin A
|
18378-89-7 |
Mithramycin A (Plicamycin, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. |
| PC-61229 |
ML-60218
|
577784-91-9 |
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively. |
| PC-45353 |
Bleomycin sulfate
|
9041-93-4 |
An anticancer agent that acts by induction of DNA strand breaks. |
| PC-45751 |
COH-29
|
1190932-38-7 |
A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM. |
| PC-42295 |
Beaucage reagent
|
66304-01-6 |
A potent DNA cleavage agent. |
