| Cat. No. |
Product Name |
Information |
| PC-70241 |
Saframycin A
|
Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro. |
| PC-70029 |
Minnelide
RNA polymerase II inhibitor
|
Minnelide is a water-soluble prodrug of triptolide, an inhibitor of RNA polymerase II-mediated transcription, also is a selective inhibitor of CIC::DUX4 sarcoma (CDS). |
| PC-45353 |
Bleomycin sulfate
|
An anticancer agent that acts by induction of DNA strand breaks. |
| PC-45751 |
COH29
Ribonucleotide reductase inhibitor
|
COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM. |
| PC-42295 |
Beaucage reagent
|
A potent DNA cleavage agent. |
| PC-45350 |
Actinomycin D
Transcription inhibitor
|
Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM. |
| PC-28440 |
RP-3467
Polθ inhibitor
|
RP-3467 is a potent, selective inhibitor of DNA polymerase theta (Polθ) helicase domain with EC50 of <0.25 nM, shows no discernible inhibitory activity against other DNA repair-related ATPases WRN, BLM, and FANCM. |
| PC-26796 |
ART615
ART558 negative control
|
ART615 is the related isomer of ART558 and ART558 negative control compound. |
| PC-26687 |
Polθ ATPase inhibitor XL-20
DNA Polθ inhibitor
|
XL-20 is a potent, selective orally bioavailable selenium-containing DNA polymerase theta (Polθ) inhibitor with IC50 of 4.3 nM for Polθ ATPase. |
| PC-26267 |
RP-4029
DNA Polθ inhibitor
|
RP-4029 is a potent, selective and covalent inhibitor of DNA polymerase θ (Polθ) with IC50 of 0.013 nM and 6.6 nM for human and mouse Polθ respectively, forms a covalent adduct with Cys2411 of human Polθ. |
| PC-26252 |
SY-589
DNA Polθ inhibitor
|
SY-589 is a highly potent, selective and orally bioavailable DNA polymerase theta (Polθ) helicase inhibitor with ATPase inhibitory IC50 of 2.29 nM in ADP-Glo assays, inhibits microhomology-mediated end joining (MMEJ) pathway. |
| PC-25301 |
NVL inhibitor MM17
NVL inhibitor
|
NVL inhibitor MM17 is a small molecule inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 0.38 uM, inhibits HCT116 growth in a dose-dependent manner with IC50 of 0.54 uM. |
