| Cat. No. |
Product Name |
Information |
| PC-45350 |
Actinomycin D
Transcription inhibitor
|
Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM. |
| PC-26267 |
RP-4029
DNA Polθ inhibitor
|
RP-4029 is a potent, selective and covalent inhibitor of DNA polymerase θ (Polθ) with IC50 of 0.013 nM and 6.6 nM for human and mouse Polθ respectively, forms a covalent adduct with Cys2411 of human Polθ. |
| PC-26252 |
SY-589
DNA Polθ inhibitor
|
SY-589 is a highly potent, selective and orally bioavailable DNA polymerase theta (Polθ) helicase inhibitor with ATPase inhibitory IC50 of 2.29 nM in ADP-Glo assays, inhibits microhomology-mediated end joining (MMEJ) pathway. |
| PC-25495 |
RP-2119
DNA Polθ inhibitor
|
RP-2119 (RP2119) is a selective, potent, and bioavailable inhibitor of DNA polymerase theta (Polθ) ATPase inhibitor with IC50 of 0.7 nM (hPOLθ ATPase) in ADP-glo assayss. |
| PC-25301 |
NVL inhibitor MM17
NVL inhibitor
|
NVL inhibitor MM17 is a small molecule inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 0.38 uM, inhibits HCT116 growth in a dose-dependent manner with IC50 of 0.54 uM. |
| PC-25300 |
MM927
NVL inhibitor
|
NVL inhibitor MM927 is a bioavailable analog of MM17 and potent inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 51 nM in cells expressing ectopic human NVL, inhibits HCT116 growth in a dose-dependent manner with IC50 of 53 nM. |
| PC-25138 |
YH-0623
POLRMT inhibitor
|
YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B. |
| PC-24672 |
SCR130
Ligase IV inhibitor, NHEJ inhibitor
|
SCR130 is a small-molecule inhibitor of nonhomologous end-joining (NHEJ), specifically inhibits Ligase IV with minimal or no effect on Ligase III and Ligase I mediated joining. |
| PC-24443 |
RTx-152
DNA Polθ inhibitor
|
RTx-152 (RTx152) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 6.2 nM, exhibits preferential killing of HR-deficient cells. |
| PC-22343 |
DNA ligase inhibitor L67
DNA ligase inhibitor
|
DNA ligase inhibitor L67 is a competitive DNA ligase inhibitor, effectively inhibits DNA ligases I/III with IC50 of 10 uM for both. |
| PC-21698 |
Fraisinib
GARS1 inhibitor
|
Fraisinib is a specific and effective inhibitor of glycyl-tRNA synthetase 1 (GARS1), suppresses the synthesis of Ap4A by GARS1 and displays strong anti-tumoral potential. |
| PC-20598 |
DNA polymerase theta inhibitor
POLθ inhibitor
|
DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity. |
