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Chemical Structure : Actinomycin D
CAS No.: 50-76-0
Catalog No.: PC-45350Not For Human Use, Lab Use Only.
Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | Get quote |
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Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM.
Actinomycin D can also interfere with DNA replication.
Actinomycin D leads to the accumulation of transcriptionally active p53 in the nucleus of HeLa, CaSki, and SiHa cells.
| M.Wt | 1255.417 | |
| Formula | C62H86N12O16 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL; DMSO: 250 mg/mL (Need ultrasonic); Methanol: 6.2 mg/mL; Methanol: 20 mg/mL (Need ultrasonic); H2O: < 12.5 mg/mL |
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| Chemical Name/SMILES |
Actinomycin D |
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1. Hietanen S, et al. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8501-6.
2. Sobell HM. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31.
3. Uberti EM, et al. Gynecol Oncol. 2009 Dec;115(3):476-81.
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