| Cat. No. |
Product Name |
Information |
| PC-25714 |
NSH76
RNA Pol I inhibitor, RRN3 inhibitor
|
NSH76 is a potent and selective RNA polymerase I (Pol I) inhibitor, inhibits Pol I-specific transcription initiation factor RRN3, selectively inhibits Pol I transcription by disrupting the Pol I pre-initiation complex. |
| PC-25710 |
RTx-303
DNA Polθ inhibitor
|
RTx-303 is a potent, selective, allosteric and orally active inhibitor of DNA polymerase θ (Polθ) with IC50 of 5.8 nM, shows no significant inhibition of other eukaryotic DNA polymerases, including the related A-family Polγ. |
| PC-24850 |
BOB-42
RNA Pol I inhibitor
|
BOB-42 is a small molecule inhibitor of RNA polymerase I (Pol I) with IC50 of 0.04 uM and 0.04 uM for degradation of RPA194 and translocation of NCL resepctively. |
| PC-24694 |
PZL-A
Mutant DNA POLγ activator
|
PZL-A is a first-in-class small-molecule activator of mitochondrial DNA (mtDNA) synthesis, potently activates mutant DNA polymerase γ (POLγ) activity with AC50 of 0.16 and 0.02 uM for POLγ mutations A467T and G848S respectively. |
| PC-24608 |
PolQi2
DNA Polϴ inhibitor
|
PolQi2 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 0.238 uM (MH-mediated deletion), inhibits the helicase activity of Polϴ. |
| PC-24607 |
PolQi1
DNA Polϴ inhibitor
|
PolQi1 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 2.48 uM (MH-mediated deletion), targets the polymerase domain of Polϴ. |
| PC-22920 |
AB25583
Polθ helicase inhibitor
|
AB25583 is a potent, specific small molecule inhibitor of SF2 DNA helicase domain of Polθ (Polθ-hel) with IC50 of 6 nM in Polθ-hel ATPase activity assay, selectively kills BRCA-deficient cells. |
| PC-22778 |
SCR7 pyrazine
DNA Ligase IV inhibitor
|
SCR7 pyrazine is a stable oxidized form of SCR7 and specific DNA Ligase IV inhibitor, inhibits nonhomologous end-joining (NHEJ) and induces cancer cell death. |
| PC-22070 |
RTx-161
DNA Polθ inhibitor
|
RTx-161 (RTx161) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 4.1 nM, exhibits preferential killing of HR-deficient cells. |
| PC-20939 |
RBI2
Ribosome biogenesis inhibitor
|
RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM. |
| PC-49690 |
Novobiocin
POLθ inhibitor, HSP90 inhibitor
|
Novobiocin (NVB, Albamycin, Cathomycin) is a potent, specific DNA polymerase theta (POLθ, POLQ) inhibitor with IC50 of 24 uM, selectively kills HR-deficient tumor cells in vitro and in vivo. |
| PC-49680 |
ART899
DNA Polθ inhibitor
|
ART899 (ART-899) is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM, shows with improved in vivo stability compared to ART558. |
