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Cat. No. Product Name CAS No. Information
PC-43493

CX-5461

1138549-36-6 Pidnarulex (CX-5461) is the first potent, selective, orally bioavailable inhibitor of RNA polymerase I, selectively inhibits rRNA synthesis in HCT-116 cells with IC50 of 142 nM, 200-fold selectivity over Pol II.
PC-62219

CX-3543

865311-47-3 CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.
PC-61229

ML-60218

577784-91-9 ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
PC-45353

Bleomycin sulfate

9041-93-4 An anticancer agent that acts by induction of DNA strand breaks.
PC-45751

COH-29

1190932-38-7 A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
PC-42295

Beaucage reagent

66304-01-6 A potent DNA cleavage agent.
PC-43227

TH-588 hydrochloride

1640282-30-9 A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM.

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