| Cat. No. |
Product Name |
Information |
| PC-27659 |
DIQ01
KHSRP inhibitor
|
DIQ01 is a specific small-molecule inhibitor of KH-type splicing regulatory protein (KHSRP), targets KH3 domain of KHSRP (MST Kd=387.4 nM) and disrupts RNA binding, exhibits potent antitumor efficacy. |
| PC-27228 |
ART6043
DNA Polθ inhibitor
|
ART6043 is a potent and selective small molecule inhibitor of DNA polymerase theta (DNA Polθ), inhibits Polθ polymerase domain (residues 1820-2590) with IC50 of 1.3 nM. |
| PC-25714 |
NSH76
RNA Pol I inhibitor, RRN3 inhibitor
|
NSH76 is a potent and selective RNA polymerase I (Pol I) inhibitor, inhibits Pol I-specific transcription initiation factor RRN3, selectively inhibits Pol I transcription by disrupting the Pol I pre-initiation complex. |
| PC-25710 |
RTx-303
DNA Polθ inhibitor
|
RTx-303 is a potent, selective, allosteric and orally active inhibitor of DNA polymerase θ (Polθ) with IC50 of 5.8 nM, shows no significant inhibition of other eukaryotic DNA polymerases, including the related A-family Polγ. |
| PC-25495 |
RP-2119
DNA Polθ inhibitor
|
RP-2119 (RP2119) is a selective, potent, and bioavailable inhibitor of DNA polymerase theta (Polθ) ATPase inhibitor with IC50 of 0.7 nM (hPOLθ ATPase) in ADP-glo assayss. |
| PC-25138 |
YH-0623
POLRMT inhibitor
|
YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B. |
| PC-24850 |
BOB-42
RNA Pol I inhibitor
|
BOB-42 is a small molecule inhibitor of RNA polymerase I (Pol I) with IC50 of 0.04 uM and 0.04 uM for degradation of RPA194 and translocation of NCL resepctively. |
| PC-24694 |
PZL-A
Mutant DNA POLγ activator
|
PZL-A is a first-in-class small-molecule activator of mitochondrial DNA (mtDNA) synthesis, potently activates mutant DNA polymerase γ (POLγ) activity with AC50 of 0.16 and 0.02 uM for POLγ mutations A467T and G848S respectively. |
| PC-24608 |
PolQi2
DNA Polϴ inhibitor
|
PolQi2 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 0.238 uM (MH-mediated deletion), inhibits the helicase activity of Polϴ. |
| PC-24607 |
PolQi1
DNA Polϴ inhibitor
|
PolQi1 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 2.48 uM (MH-mediated deletion), targets the polymerase domain of Polϴ. |
| PC-22920 |
AB25583
Polθ helicase inhibitor
|
AB25583 is a potent, specific small molecule inhibitor of SF2 DNA helicase domain of Polθ (Polθ-hel) with IC50 of 6 nM in Polθ-hel ATPase activity assay, selectively kills BRCA-deficient cells. |
| PC-22778 |
SCR7 pyrazine
DNA Ligase IV inhibitor
|
SCR7 pyrazine is a stable oxidized form of SCR7 and specific DNA Ligase IV inhibitor, inhibits nonhomologous end-joining (NHEJ) and induces cancer cell death. |
