| Cat. No. |
Product Name |
Information |
| PC-49348 |
RP-6685
DNA Polθ inhibitor
|
RP-6685 (RP6685) is a potent, selective and orally bioavailable inhibitor of DNA polymerase theta (Polθ) with IC50 of 5.8 nM in PicoGreen assay (0.3 nM Polθ enzyme). |
| PC-73404 |
Bersiporocin
PRS inhibitor
|
Bersiporocin (DWN 12088) is an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor with antifibrotic effect. |
| PC-35725 |
SEC inhibitor KL-2
cyclin T1-AFF4 inhibitor
|
SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC. |
| PC-35724 |
SEC inhibitor KL-1
cyclin T1-AFF4 inhibitor
|
SEC inhibitor KL-1 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=3.48 uM) within SEC. |
| PC-43493 |
CX-5461
RNA Pol I inhibitor
|
Pidnarulex (CX-5461) is the first potent, selective, orally bioavailable inhibitor of RNA polymerase I, selectively inhibits rRNA synthesis in HCT-116 cells with IC50 of 142 nM, 200-fold selectivity over Pol II. |
| PC-63201 |
PNR-7-02
DNA Polη inhibitor
|
PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols. |
| PC-43056 |
BMH-21
RNA Pol I inhibitor
|
BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription. |
| PC-62219 |
CX-3543
|
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells. |
| PC-61350 |
Mithramycin A
|
Mithramycin A (Plicamycin, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. |
| PC-61229 |
ML-60218
|
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively. |
| PC-45353 |
Bleomycin sulfate
|
An anticancer agent that acts by induction of DNA strand breaks. |
| PC-45751 |
COH-29
|
A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM. |
