| Cat. No. |
Product Name |
Information |
| PC-38616 |
Lurbinectedin
DNA covalent binder
|
Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively. |
| PC-38571 |
L189
DNA ligase inhibitor
|
L189 is a small moelcule DNA ligase I, III and IV inhibitor with IC50 of 5, 9 and 5 uM, blocks DNA ligase I DNA binding activity with Ki of 5 uM. |
| PC-73357 |
Pyridostatin
G-quadruplex stabilizer
|
Pyridostatin (RR82) is a high-affinity G-quadruplex-stabilizing small molecule (Kd=490 nM), promotes the folding of telomeric G-quadruplexes, induces DNA damage and cell cycle arrest. |
| PC-43167 |
SCR7
|
SCR7 is a specific inhibitor of nonhomologous end-joining (NHEJ), blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I. |
| PC-42973 |
Cycloheximide
|
Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. |
| PC-70241 |
Saframycin A
|
A heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro. |
