| Cat. No. |
Product Name |
Information |
| PC-45353 |
Bleomycin sulfate
|
An anticancer agent that acts by induction of DNA strand breaks. |
| PC-45751 |
COH29
Ribonucleotide reductase inhibitor
|
COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM. |
| PC-42295 |
Beaucage reagent
|
A potent DNA cleavage agent. |
| PC-45350 |
Actinomycin D
Transcription inhibitor
|
Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM. |
| PC-22343 |
DNA ligase inhibitor L67
DNA ligase inhibitor
|
DNA ligase inhibitor L67 is a competitive DNA ligase inhibitor, effectively inhibits DNA ligases I/III with IC50 of 10 uM for both. |
| PC-21698 |
Fraisinib
GARS1 inhibitor
|
Fraisinib is a specific and effective inhibitor of glycyl-tRNA synthetase 1 (GARS1), suppresses the synthesis of Ap4A by GARS1 and displays strong anti-tumoral potential. |
| PC-20939 |
RBI2
Ribosome biogenesis inhibitor
|
RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM. |
| PC-20598 |
DNA polymerase theta inhibitor
POLθ inhibitor
|
DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity. |
| PC-38801 |
Congo red
DNA Pol γ inhibitor
|
Congo red (Zinc 03830554) is a high-affinity small molecule targeting mitochondrial DNA polymerase gamma (Pol γ), selectively kills MLH1 deficient cancer cells. |
