Plicamycin | Sp1 inhibitor | Probechem Biochemicals

Chemical Structure : Plicamycin

CAS No.: 18378-89-7

Plicamycin (Mithramycin A, PA 144, NSC 24559)

Catalog No.: PC-61350Not For Human Use, Lab Use Only.

Plicamycin (Mithramycin A, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA, inhibits specificity protein 1 (Sp1) transcription factor.

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2 mg	$188	In stock
5 mg	$328	In stock
10 mg	$528	In stock
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Biological Activity

Plicamycin (Mithramycin A, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA, inhibits specificity protein 1 (Sp1) transcription factor.
Plicamycin binds to the minor groove of DNA at GC-rich sites, induces cancer cell apoptosis and metastasis.

Physicochemical Properties

M.Wt	1085
Formula	C52H76O24
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-3-((1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl)-2-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4-(((2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-

References

1. Boro A, et al. Int J Cancer. 2012 Nov 1;131(9):2153-64.

2. Lee TJ, et al. Mol Cancer Ther. 2006 Nov;5(11):2737-46.

3. Majee S, et al. Biochem Pharmacol. 1999 May 1;57(9):981-7.

Plicamycin (Mithramycin A, PA 144, NSC 24559)

Biological Activity

Physicochemical Properties

References

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