| Cat. No. |
Product Name |
Information |
| PC-22043 |
SIC-19
SIK2 inhibitor, SIK2 degrader
|
SIC-19 is a potent, selective SIK2 inhibitor, promotes SIK2 protein degradation via the ubiquitination pathway, exhibits synthetic lethality with PARP inhibitors in ovarian cancer. |
| PC-21590 |
HG-9-91-01
SIK inhibitor
|
HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. |
| PC-21587 |
GLPG3312
SIK inhibitor
|
GLPG3312 is a potent and selective pan-SIK inhibitor with IC50 of 2.0/0.7/0.6 nM for SIK1/SIK2/SIK3, respectively. |
| PC-21585 |
JRD-SIK1/2i-4
SIK1/2 inhibitor
|
JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation. |
| PC-20664 |
GLPG3970
SIK2/3 inhibitor
|
GLPG3970 (GLPG 3970) is a potent, selective first-in-class salt inducible kinase SIK2/SIK3 inhibitor with IC50 of 7.8/3.8 nM, respectively. |
| PC-49563 |
SK-124
SIK2/SIK3 inhibitor
|
SK-124 (SK124) is a potent, selective, orally active SIK2/SIK3 inhibitor with IC50 of 8.8/11.3 nM in cell-based NanoBRET assays, 15-fold selectivity versus SIK1. |
| PC-72723 |
MRIA9
dual SIK/PAK inhibitor
|
MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively. |
| PC-63124 |
rac Pterosin B
SIK3 inhibitor
|
rac Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain. |
| PC-63123 |
Pterosin B
SIK3 inhibitor
|
Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain. |
| PC-63122 |
YKL-06-061
SIK inhibitor
|
YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively. |
| PC-61952 |
ARN3261
SIK2/3 inhibitor
|
ARN3261 (GRN-300, ARN-3261) is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively. |
| PC-61766 |
ARN-3236
SIK2 inhibitor
|
ARN-3236 (ARN3236) is a novel potent, selective, and orally active SIK2 inhibitor with IC50 of <1 nM. |
