Chemical Structure : JRD-SIK1/2i-4
CAS No.:
2810810-00-3
JRD-SIK1/2i-4
Catalog No.: PC-21585Not For Human Use, Lab Use Only.
JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation.
JRD-SIK1/2i-4 inhibits key intracellular proximal signaling events including reducing phosphorylation of the SIK substrate cAMP response element binding protein (CREB) regulated transcription coactivator 3 (CRTC3).
JRD-SIK1/2i-4 inhibits inflammatory cytokine production in primary human macrophages stimulated with TLR7/8-agonist R848.
JRD-SIK1/2i-4 suppresses IL-2 production by activated primary T cells, ameliorates disease in a murine colitis model.
Physicochemical Properties
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M.Wt
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388.43
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Formula
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C21H20N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(5-(2-cyano-5-((1-methylazetidin-3-yl)oxy)pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
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References
1. Babbe H, et al. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307086120.
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