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Chemical Structure : JRD-SIK1/2i-4
Catalog No.: PC-21585Not For Human Use, Lab Use Only.
JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation.
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JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation.
JRD-SIK1/2i-4 inhibits key intracellular proximal signaling events including reducing phosphorylation of the SIK substrate cAMP response element binding protein (CREB) regulated transcription coactivator 3 (CRTC3).
JRD-SIK1/2i-4 inhibits inflammatory cytokine production in primary human macrophages stimulated with TLR7/8-agonist R848.
JRD-SIK1/2i-4 suppresses IL-2 production by activated primary T cells, ameliorates disease in a murine colitis model.
| M.Wt | 388.43 | |
| Formula | C21H20N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Babbe H, et al. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307086120.
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