| Cat. No. |
Product Name |
Information |
| PC-22565 |
Fludarabine
STAT1 inhibitor, NAT10 inhibitor
|
Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes. |
| PC-21893 |
Stattic
STAT3 inhibitor
|
Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro. |
| PC-20934 |
WB737
STAT3 inhibitor
|
WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM. |
| PC-20634 |
IST5-002
Stat5a/b inhibitor
|
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells. |
| PC-20465 |
S3I-201
STAT3 inhibitor
|
S3I-201 (NSC 74859) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM. |
| PC-20357 |
HP590
STAT3 inhibitor
|
HP590 is a highly potent, and orally bioavailable STAT3 inhibitor with IC50 of 27.8 nM, inibits IL-6 induced of the p-STAT3 Tyr705 and p-Ser727 activation in GC cells with lower nanomolar inhibitory activity. |
| PC-20120 |
K1836
STAT3 inhibitor
|
K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling, blocks STAT3 phosphorylation. |
| PC-20066 |
W1046
STAT3 inhibitor
|
W1046 is a potent and selective STAT3 inhibitor, decreases the expression of VISTA at mRNA and protein level and inhibits proliferation and survival in AML cells. |
| PC-49596 |
SOST inhibitor S6
Sclerostin inhibitor
|
SOST inhibitor S6 is a small-molecule targeting Sclerostin (SOST), blocks STAT3 binding to SOST, inhibits breast cancer bone metastasis. |
| PC-49462 |
WB436B
STAT3 inhibitor
|
WB436B is a potent and highly selective small molecule inhibitor of STAT3, specifically targets the STAT3-SH2 domain with KD value of 94.3 nM. |
| PC-49434 |
DR-1-55
STAT3 inhibitor
|
DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3. |
| PC-49156 |
KS10076
STAT3 inhibitor, Metal chelator
|
KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM. |
