| Cat. No. |
Product Name |
Information |
| PC-28163 |
Atovaquone
Antimalaria, STAT3 inhibitor, STK31 inhibitor
|
Atovaquone is a broad-spectrum anti-protozoal agent, inhibits electron transport in protozoa by targeting cytochrome bc1 complex, is also a potent STAT3 inhibitor that reduces STAT3 phosphorylation, target gene expression, and viability of STAT3-dependent cancer cells. |
| PC-27106 |
W1307
STAT3 inhibitor
|
W1307 is a potent and highly selective STAT3 inhibitor with SPR KD of 1.74 uM, demonstrates significant anti-tumor activity both in vitro and in vivo. |
| PC-27061 |
STAT6-IN-10
STAT6 inhibitor
|
STAT6-IN-10 is a potent, selective STAT6 (signal transducer and activator of transcription 6) inhibitor with EC50 of 2 nM, inhibits secretion of CCL17 in human peripheral whole blood. |
| PC-26446 |
ISS610
STAT3 inhibitor
|
ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1. |
| PC-26212 |
Pomstafib-2-CR
STAT5b inhibitor
|
Pomstafib-2-CR is the ester prodrug of Stafib-2-CR, which is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM. |
| PC-26211 |
Stafib-2-CR
STAT5b inhibitor
|
Stafib-2-CR is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM, shows 69-fold selectivity over STAT5a. |
| PC-25691 |
STAT6-IN-14
STAT6 inhibitor
|
STAT6-IN-14 is a potent, selective STAT6 inhibitor with IC50 of 1.2 uM in STAT6 reporter assay using STAT6-HEK293 cells. |
| PC-25579 |
Bt354
STAT3 inhibitor
|
Bt354 is a specific, small-molecule inhibitor of the STAT3 signalling pathway, prevents STAT3 from entering the nucleus and phosphorylates it at Y705, exhibiting potent anticancer properties. |
| PC-25480 |
Stafori-2
STAT4 inhibitor
|
Stafori-2 is the phosphate analog of Stafori-1 and potent, selective small molecule inhibitor of STAT4 Src homology 2 domain with Ki of 0.18 uM in FP assays, shows good selectivity over other STAT family members. |
| PC-25257 |
WR-S-462
STAT3 inhibitor
|
WR-S-462 is a highly potent and selective STAT3 inhibitor with SPR Kd of 58 nM, directly interferes with the STAT3-SH2 domain interaction. |
| PC-25250 |
STAT3 inhibitor W36
STAT3 inhibitor
|
STAT3 inhibitor W36 is a potent, selective STAT3 inhibitor with SPR KD of 323.3 nM, inhibits IL-6/JAK/STAT3 signaling pathway with IC50 of 0.87 uM in HEK-Blue-IL-6 cell model. |
| PC-24861 |
STAT6-IN-5
STAT6 inhibitor
|
STAT6-IN-5 (compound 84) is a potent, selective STAT6 inhibitor with IC50 of 0.24 uM, compound 84 extracted from patent WO2024071439 A1. |
