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Cat. No. Product Name Information
PC-21893

Stattic

STAT3 inhibitor

Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro.
PC-20934

WB737

STAT3 inhibitor

WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM.
PC-20634

IST5-002

Stat5a/b inhibitor

IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells.
PC-20465

S3I-201

STAT3 inhibitor

S3I-201 (NSC 74859) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM.
PC-20357

HP590

STAT3 inhibitor

HP590 is a highly potent, and orally bioavailable STAT3 inhibitor with IC50 of 27.8 nM, inibits IL-6 induced of the p-STAT3 Tyr705 and p-Ser727 activation in GC cells with lower nanomolar inhibitory activity.
PC-20120

K1836

STAT3 inhibitor

K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling, blocks STAT3 phosphorylation.
PC-20066

W1046

STAT3 inhibitor

W1046 is a potent and selective STAT3 inhibitor, decreases the expression of VISTA at mRNA and protein level and inhibits proliferation and survival in AML cells.
PC-49596

SOST inhibitor S6

Sclerostin inhibitor

SOST inhibitor S6 is a small-molecule targeting Sclerostin (SOST), blocks STAT3 binding to SOST, inhibits breast cancer bone metastasis.
PC-49462

WB436B

STAT3 inhibitor

WB436B is a potent and highly selective small molecule inhibitor of STAT3, specifically targets the STAT3-SH2 domain with KD value of 94.3 nM.
PC-49434

DR-1-55

STAT3 inhibitor

DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3.
PC-49156

KS10076

STAT3 inhibitor, Metal chelator

KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM.
PC-49088

STX-0119

STAT3 inhibitor

STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM.

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