| Cat. No. |
Product Name |
Information |
| PC-24072 |
Angoline
IL6/STAT3 inhibitor
|
Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis. |
| PC-23511 |
HJC0416 hydrochloride
STAT3 inhibitor
|
HJC0416 hydrochloride is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM. |
| PC-23165 |
K2071
STAT3 inhibitor
|
K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines. |
| PC-22565 |
Fludarabine
STAT1 inhibitor, NAT10 inhibitor
|
Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes. |
| PC-22095 |
YY002
STAT3 inhibitor
|
YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation. |
| PC-21893 |
Stattic
STAT3 inhibitor
|
Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro. |
| PC-21874 |
WZ-2-033
STAT3 inhibitor
|
WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling. |
| PC-20934 |
WB737
STAT3 inhibitor
|
WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM. |
| PC-20636 |
MNS1-Leu
STAT3 inhibitor
|
MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20635 |
MNS1-MV
STAT3 inhibitor
|
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20634 |
IST5-002
Stat5 inhibitor
|
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells. |
| PC-20632 |
STAT3 inhibitor LY5
STAT3 inhibitor
|
STAT3 inhibitor LY5 is a specfic STAT3 small molecule inhibitor, binds to STAT3 SH2 domain wioth Kd of 2.5 uM. |
