| Cat. No. |
Product Name |
Information |
| PC-24629 |
PMM-172
STAT3 inhibitor
|
PMM-172 is a specific small molecule STAT3 inhibitor targeting STAT3 SH2 domain, inhibits STAT3 downstream target genes expression, shows anti-proliferative activity against MDA-MB-231 cells with IC50 of 1.98 uM. |
| PC-24623 |
RDp002
STAT3 inhibitor
|
RDp002 is a potent novel small molecule STAT3 inhibitor, interacts with STAT3 SH2 domain with KD of 4.23 uM, inhibits STAT3 phosphorylation of STAT3 at tyrosine 705 and serine 727 residues. |
| PC-24431 |
STAT3 inhibitor K116
STAT3 inhibitor
|
K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines. |
| PC-24308 |
Hygromycin B
CHI3L1-STAT3 inhibitor
|
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells, also an inhibitor of the STAT3-CCD domain, disrupts the CHI3L1-STAT3 interaction, inhibits glioblastoma both in vitro and in vivo. |
| PC-24234 |
Stafori-1
STAT4 inhibitor
|
Stafori-1 is the first specific small-molecule inhibitor of STAT4, inhibits the protein-protein interaction domain of STAT4, the SH2 domain, with Ki of 1.7 uM, 10-70-fold selectivity over other STAT proteins. |
| PC-24072 |
Angoline
IL6/STAT3 inhibitor
|
Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis. |
| PC-24045 |
STAT3 inhibitor NA16
STAT3 inhibitor
|
STAT3 inhibitor NA16 is a nifuroxazide analog and STAT3 inhibitor, downregulates FoxP3 expression with IC50 of 4.7 uM in TCR-stimulated total T cells. |
| PC-24028 |
Niclosamide
STAT3 inhibitor
|
Niclosamide (BAY2353) is an orally active antihelminthic agent, also is a STAT3 inhibitor with IC50 of 0.25 uM in HeLa cells. |
| PC-23197 |
Scutellarin
STAT3 inhibitor
|
Scutellarin is an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, also shows anti-HIV-1 activity. |
| PC-23177 |
AK-068
STAT6 inhibitor
|
AK-068 is a highly potent, selective STAT6 ligand / inhibitor with Ki of 6 nM, binds to STAT6 SH2 domain. |
| PC-23165 |
K2071
STAT3 inhibitor
|
K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines. |
| PC-20636 |
MNS1-Leu
STAT3 inhibitor
|
MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
