STAT compound (inhibitors, antagonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-20628	S3I-1757 STAT3 inhibitor	S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.
PC-20627	W2014-S STAT3 inhibitor	W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.
PC-20605	STAT3 inhibitor DG-4 TrxR1 inhibitor	DG-4 is a potent, selective inhibitor of STAT3-dependent transcription with IC50 of 0.12 uM in IL6-STAT3 luciferase reporter assays, 44-fold selectivity over IFN-γ STAT1.
PC-38627	STAT3 inhibitor N4 STAT3 inhibitor	STAT3 inhibitor N4 is a small molecule capable of inhibiting the STAT3 SH2 domain with IC50 of 0.57 uM, SPR KD of 1.04 uM, inhibits STAT3 dimerization and transcription in vitro and suppresses pancreatic cancer in vivo.
PC-70276	OPB-51602	A novel small molecule SH2 domain-targeting STAT3 inhibitor with IC50/Kd of 7.3/5 nM.

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