| Cat. No. |
Product Name |
Information |
| PC-70361 |
Piperlongumine
STAT3 inhibitor
|
Piperlongumine (Piplartine) is a naturally occurring small molecule recently identified to be toxic selectively to cancer cells in vitro and in vivo, binds and targets STAT3 Cys712 residue. |
| PC-70277 |
OPB-31121
|
OPB-31121 (OPB31121) is a novel STAT3 inhibitor (IC50=18.7 nM, Kd=10 nM) that strongly inhibits STAT3 and STAT5 phosphorylation without upstream kinase inhibition. |
| PC-61169 |
Pomstafib-2
STAT5b inhibitor
|
Pomstafib-2 is the pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM. |
| PC-61168 |
Pomstafib-1
STAT5b inhibitor
|
Pomstafib-1 is the cell-permeable, pivaloyloxymethylester of Stafib-1, which is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a. |
| PC-61167 |
Stafib-2
STAT5b inhibitor
|
Stafib-2 (Stafib 2) is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a.. |
| PC-61166 |
Stafib-1
STAT5b inhibitor
|
Stafib-1 is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a. |
| PC-61162 |
C188-9
STAT3 inhibitor
|
C188-9 (TTI-101) is a novel small-molecule STAT3 inhibitor with Ki of 12.4 nM. |
| PC-61161 |
MM-206
STAT3 inhibitor
|
MM-206 is a novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD). |
| PC-61140 |
Galiellalactone
STAT3 inhibitor
|
Galiellalactone is a small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM, blocks the binding of the activated STAT3 dimers to DNA. |
| PC-61139 |
GPA 512
STAT3 inhibitor
|
GPA512 is the orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes. |
| PC-61125 |
STAT5 inhibitor 17f
STAT5 inhibitor
|
A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation. |
| PC-61033 |
Erasin
STAT3 inhibitor
|
Erasin is a potent, selective STAT3 inhibitor with IC50 of 9.7 uM, inhibits tyrosine phosphorylation of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. |
