| Cat. No. |
Product Name |
Information |
| PC-60659 |
ML116
STAT3 inhibitor
|
ML116 is a selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM). |
| PC-60658 |
CPA7
STAT3 inhibitor
|
STAT3 inhibitor CPA7 is a platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells. |
| PC-60500 |
HJC0416
STAT3 inhibitor
|
HJC0416 is an orally bioavailable small-molecule STAT3 inhibitor. |
| PC-60456 |
Cucurbitacin I
JAK/STAT3 inhibitor
|
Cucurbitacin I (JSI-124) is a triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM. |
| PC-60417 |
Debio 0617B
Multi-kinases inhibitor
|
Debio 0617B is a first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM). |
| PC-42174 |
BP-1-102
STAT3 inhibitor
|
BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM. |
| PC-42160 |
HO-3867
STAT3 inhibitor
|
HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. |
| PC-42175 |
SH5-07
|
SH5-07 (SH-5-07, SH 5-07) is a potent, selective small-molecule STAT3 inhibitor with IC50 of 3.9 uM. |
| PC-45109 |
SH-4-54
|
SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM. |
| PC-43790 |
Napabucasin
STAT3 inhibitor
|
Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM). |
| PC-42210 |
AS1517499
STAT6 inhibitor
|
AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay. |
| PC-22565 |
Fludarabine
STAT1 inhibitor
|
Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes. |
