MM-206 |CAS:1809581-87-0 Probechem Biochemicals

Chemical Structure : MM-206

MM-206 (MM206;MM 206)

Catalog No.: PC-61161Not For Human Use, Lab Use Only.

MM-206 is a novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD).

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Biological Activity

MM-206 is a novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD).
MM-206 also inhibits G-CSF-induced STAT3 phosphorylation in AML cell lines with IC50 of 0.8-1.9 uM,

Physicochemical Properties

M.Wt	497.454
Formula	C22H12F5NO3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3,4,5,6-pentafluoro-N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)benzenesulfonamide

References

1. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9.

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MM-206 (MM206;MM 206)

Biological Activity

Physicochemical Properties

References

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