| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-38208 |
ARN23765
|
2244458-40-8 |
ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays. |
| PC-60232 |
GLPG-1837
|
1654725-02-6 |
A potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively. |
| PC-60231 |
GLPG-2222
|
1918143-53-9 |
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM. |
| PC-49187 |
GLPG2451
|
2055015-61-5 |
GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation, improves the gating function of the CFTR channel. |
| PC-38707 |
ABBV-3221
|
2222264-64-2 |
ABBV-3221 (GLPG-3221) is a highly potent CFTR C2 corrector with HBE-TECC EC50 of 1055 nM. |
| PC-38357 |
Dirocaftor
|
2137932-23-9 |
Dirocaftor (PTI-808) is a potent small molecule CFTR potentiator that enhances the function of CFTR protein by opening chloride channels, shows potential for treatment of of cystic fibrosis (CF). |
| PC-73453 |
Vanzacaftor
|
2374124-49-7 |
Vanzacaftor is a potent, selective cystic fibrosis transmembrane regulator (CFTR)
protein modulator with potential for treatment of cystic fibrosis. |
