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Cat. No. Product Name CAS No. Information
PC-38208

ARN23765

2244458-40-8 ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays.
PC-60232

GLPG-1837

1654725-02-6 A potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.
PC-60231

GLPG-2222

1918143-53-9 GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.
PC-49187

GLPG2451

2055015-61-5 GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation, improves the gating function of the CFTR channel.
PC-38707

ABBV-3221

2222264-64-2 ABBV-3221 (GLPG-3221) is a highly potent CFTR C2 corrector with HBE-TECC EC50 of 1055 nM.
PC-38357

Dirocaftor

2137932-23-9 Dirocaftor (PTI-808) is a potent small molecule CFTR potentiator that enhances the function of CFTR protein by opening chloride channels, shows potential for treatment of of cystic fibrosis (CF).
PC-73453

Vanzacaftor

2374124-49-7 Vanzacaftor is a potent, selective cystic fibrosis transmembrane regulator (CFTR)
protein modulator with potential for treatment of cystic fibrosis.

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