| Cat. No. |
Product Name |
Information |
| PC-22440 |
I1421
CFTR potentiator
|
I1421 is a potent, small molecule CFTR potentiator with EC50 of 64 nM. |
| PC-21956 |
CFTR(inh)-172
CFTR inhibitor
|
CFTR(inh)-172 is a potent and selective blocker/inhibitor of CFTR chloride channel with Ki of 200 nM, reversibly inhibits CFTR short-circuit currents. |
| PC-20491 |
VX-661
CFTR corrector
|
Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport. |
| PC-49187 |
GLPG2451
F508del CFTR potentiator
|
GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation. |
| PC-38707 |
ABBV-3221
CFTR corrector
|
ABBV-3221 (GLPG-3221) is a highly potent CFTR corrector with HBE-TECC EC50 of 105 nM. |
| PC-38357 |
Dirocaftor
CFTR potentiator
|
Dirocaftor (PTI-808) is a potent small molecule CFTR potentiator that enhances the function of CFTR protein by opening chloride channels, shows potential for treatment of of cystic fibrosis (CF). |
| PC-73453 |
Vanzacaftor
CFTR corrector
|
Vanzacaftor (VX-121) is a potent, selective cystic fibrosis transmembrane regulator (CFTR) corrector, with potential for treatment of cystic fibrosis. |
| PC-73345 |
SRI-41315
eRF1 degrader
|
SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations. |
| PC-73172 |
Elexacaftor
CFTR corrector
|
Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector and modulator for cystic fibrosis treatment. |
| PC-72975 |
Bamocaftor
CFTR corrector
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-72974 |
Bamocaftor potassium
CFTR corrector
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-72256 |
CP-628006
CFTR potentiator
|
CP-628006 (CP628006) is a small molecule CFTR potentiator, potentiates low temperature-rescued F508del-CFTR with EC50 of 0.4 uM. |
