| Cat. No. |
Product Name |
Information |
| PC-49187 |
GLPG2451
F508del CFTR potentiator
|
GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation. |
| PC-73345 |
SRI-41315
eRF1 degrader
|
SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations. |
| PC-73172 |
Elexacaftor
CFTR corrector
|
Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector and modulator for cystic fibrosis treatment. |
| PC-72975 |
Bamocaftor
CFTR corrector
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-72974 |
Bamocaftor potassium
CFTR corrector
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-38208 |
ARN23765
CFTR corrector
|
ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays. |
| PC-43442 |
VX-809
CFTR corrector
|
VX-809 (Lumacaftor, VRT 826809) is a potent CFTR corrector that increases F508del-CFTR-mediated chloride transport amd improves F508del-CFTR maturation in FRT cells with EC50 of 0.1 and 0.5 uM, respectively. |
| PC-43325 |
Ivacaftor
CFTR potentiator
|
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
| PC-60652 |
Corr4A
CFTR corrector
|
Corr4A is a small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM. |
| PC-60232 |
GLPG-1837
|
A potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively. |
| PC-60231 |
GLPG-2222
CFTR corrector
|
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM. |
| PC-22024 |
FDL169
CFTR corrector
|
FDL169 (FDL-169) is a novel F508del-CFTR corrector, restores the function of the defective CFTR protein. |
