| Cat. No. |
Product Name |
Information |
| PC-35461 |
Olacaftor
CFTR corrector
|
Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, shows the potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis. |
| PC-43442 |
Lumacaftor
CFTR corrector, DUSP18 inhibitor
|
VX-809 (Lumacaftor, VRT 826809) is a potent CFTR corrector that increases F508del-CFTR-mediated chloride transport amd improves F508del-CFTR maturation in FRT cells with EC50 of 0.1 and 0.5 uM, respectively, also inhibits dual specificity phosphatase 18 (DUSP18). |
| PC-43325 |
Ivacaftor
CFTR potentiator
|
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
| PC-60652 |
Corr4A
CFTR corrector
|
Corr4A is a small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM. |
| PC-70168 |
OSSK-630513
CFTR potentiator
|
OSSK-630513 is a novel potent CFTR potentiator with Kd of 31.7 nM. |
| PC-70167 |
OSSK-674842
CFTR potentiator
|
A novel potent CFTR potentiator that blocks hCFTR with apparent Kd of 71.3 uM. |
| PC-60232 |
GLPG1837
CFTR potentiator
|
GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively. |
| PC-60231 |
GLPG-2222
CFTR corrector
|
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM. |
| PC-45712 |
BPO-27 racemate
CFTR inhibitor
|
BPO-27 is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM). |
| PC-45770 |
KM11060
CFTR corrector
|
KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h). |
| PC-45455 |
GlyH-101
CFTR inhibitor
|
GlyH-101 is a potent CFTR inhibitor with Ki of 4.3 uM. |
| PC-45456 |
IOWH-032
CFTR inhibitor, SARS-CoV-2 Nsp13 inhibitor
|
IOWH-032 is a potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis. |
