| Cat. No. |
Product Name |
Information |
| PC-22023 |
Posenacaftor sodium
CFTR corrector
|
Posenacaftor (PTI-801) sodium is a newly developed p.Phe508del-CFTR corrector with EC50 of 0.52 uM (HS-YFP quenching rate). |
| PC-22022 |
Posenacaftor
CFTR corrector
|
Posenacaftor (PTI-801) is a newly developed p.Phe508del-CFTR corrector with EC50 of 0.52 uM (HS-YFP quenching rate). |
| PC-21956 |
CFTR(inh)-172
CFTR inhibitor
|
CFTR(inh)-172 is a potent and selective blocker/inhibitor of CFTR chloride channel with Ki of 200 nM, reversibly inhibits CFTR short-circuit currents. |
| PC-20491 |
VX-661
CFTR corrector
|
Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport. |
| PC-38707 |
ABBV-3221
CFTR corrector
|
ABBV-3221 (GLPG-3221) is a highly potent CFTR C2 corrector with HBE-TECC EC50 of 1055 nM. |
| PC-38357 |
Dirocaftor
CFTR potentiator
|
Dirocaftor (PTI-808) is a potent small molecule CFTR potentiator that enhances the function of CFTR protein by opening chloride channels, shows potential for treatment of of cystic fibrosis (CF). |
| PC-73453 |
Vanzacaftor
CFTR modulator
|
Vanzacaftor is a potent, selective cystic fibrosis transmembrane regulator (CFTR)
protein modulator with potential for treatment of cystic fibrosis. |
| PC-72256 |
CP-628006
CFTR potentiator
|
CP-628006 (CP628006) is a small molecule CFTR potentiator, potentiates low temperature-rescued F508del-CFTR with EC50 of 0.4 uM. |
| PC-35461 |
Olacaftor
|
Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, shows the potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis.. |
| PC-43327 |
Ivacaftor hydrate
|
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
| PC-43326 |
Ivacaftor benzenesulfonate
|
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
| PC-70168 |
OSSK-630513
|
A novel potent CFTR potentiator with Kd of 31.7 nM. |
