| Cat. No. |
Product Name |
Information |
| PC-60232 |
GLPG1837
CFTR potentiator
|
GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively. |
| PC-60231 |
GLPG-2222
CFTR corrector
|
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM. |
| PC-45712 |
BPO-27 racemate
CFTR inhibitor
|
BPO-27 is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM). |
| PC-45770 |
KM11060
CFTR corrector
|
KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h). |
| PC-45455 |
GlyH-101
CFTR inhibitor
|
GlyH-101 is a potent CFTR inhibitor with Ki of 4.3 uM. |
| PC-45456 |
IOWH-032
CFTR inhibitor
|
IOWH-032 is a potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis. |
| PC-45711 |
(R)-BPO-27
CFTR inhibitor
|
(R)-BPO-27, the R enantiomer of BPO-27, CFTR chloride conductance inhibitor with IC50 of 4 nM. |
| PC-22440 |
I1421
CFTR potentiator
|
I1421 is a potent, small molecule CFTR potentiator with EC50 of 64 nM. |
| PC-22024 |
FDL169
CFTR corrector
|
FDL169 (FDL-169) is a novel F508del-CFTR corrector, restores the function of the defective CFTR protein. |
| PC-22023 |
Posenacaftor sodium
CFTR corrector
|
Posenacaftor (PTI-801) sodium is a newly developed p.Phe508del-CFTR corrector with EC50 of 0.52 uM (HS-YFP quenching rate). |
| PC-22022 |
Posenacaftor
CFTR corrector
|
Posenacaftor (PTI-801) is a newly developed p.Phe508del-CFTR corrector with EC50 of 0.52 uM (HS-YFP quenching rate). |
| PC-21956 |
CFTR(inh)-172
CFTR inhibitor
|
CFTR(inh)-172 is a potent and selective blocker/inhibitor of CFTR chloride channel with Ki of 200 nM, reversibly inhibits CFTR short-circuit currents. |
