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Cat. No. Product Name CAS No. Information
PC-60232

GLPG-1837

1654725-02-6 A potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.
PC-60231

GLPG-2222

1918143-53-9 GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.
PC-38707

ABBV-3221

2222264-64-2 ABBV-3221 (GLPG-3221) is a highly potent CFTR C2 corrector with HBE-TECC EC50 of 1055 nM.
PC-38357

Dirocaftor

2137932-23-9 Dirocaftor (PTI-808) is a potent small molecule CFTR potentiator that enhances the function of CFTR protein by opening chloride channels, shows potential for treatment of of cystic fibrosis (CF).
PC-73453

Vanzacaftor

2374124-49-7 Vanzacaftor is a potent, selective cystic fibrosis transmembrane regulator (CFTR)
protein modulator with potential for treatment of cystic fibrosis.
PC-73345

SRI-41315

1613509-49-1 SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.
PC-73172

Elexacaftor

2216712-66-0 Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector and modulator for cystic fibrosis treatment.

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