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Chemical Structure : GLPG2451
CAS No.: 2055015-61-5
Catalog No.: PC-49187Not For Human Use, Lab Use Only.
GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | $768 | In stock | |
| 100 mg | Get quote |
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GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.
GLPG2451 improves the gating function of the CFTR channel.
| M.Wt | 419.375 | |
| Formula | C16H16F3N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-amino-N-(2-hydroxypropyl)-5-((4-(trifluoromethoxy)phenyl)sulfonyl)picolinamide |
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1. Gees M, et al. Front Pharmacol. 2018 Oct 26;9:1221.
2. Van der Plas SE, et al. J Med Chem. 2021 Jan 14;64(1):343-353.
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