| Cat. No. |
Product Name |
Information |
| PC-20666 |
BAY 2965501
|
BAY2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill. |
| PC-38842 |
JNJ-3790339
|
JNJ-3790339 is a potent and selective inhibitor of diacylglycerol kinase α (DGKα), demonstrates similar cytotoxicity in GBM and melanoma cells as ritanserin. |
| PC-63497 |
CU-3
|
CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region. |
| PC-70274 |
R 59022
|
R 59022 is a small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets. |
| PC-21287 |
BMS-684
|
BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α(DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases. |
| PC-21185 |
Atractylenolide II
|
Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay). |
| PC-20914 |
BMS-502
|
BMS-502 (BMS 502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively. |
