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BAY 2965501

BAY2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill.


JNJ-3790339 is a potent and selective inhibitor of diacylglycerol kinase α (DGKα), demonstrates similar cytotoxicity in GBM and melanoma cells as ritanserin.


CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region.

R 59022

R 59022 is a small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets.


BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α(DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.

Atractylenolide II

Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).


BMS-502 (BMS 502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.

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