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ASP1570

Chemical Structure : ASP1570

CAS No.: 2660218-70-0

ASP1570 (Alcudacigib, ASP-1570)

Catalog No.: PC-24317Not For Human Use, Lab Use Only.

ASP1570 (Alcudacigib) is a potent, selective diacylglycerol kinase ζ (DGK zeta, DGKζ) inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ASP1570 (Alcudacigib) is a potent, selective diacylglycerol kinase ζ (DGK zeta, DGKζ) inhibitor.
    ASP1570 enhanced T-cell activation with increased diacylglycerol downstream signaling and released anergic T cells from their hyporesponsive state.
    ASP1570 restored T-cell functions suppressed by multiple immunosuppressive signals (TGF-β, PGE2, adenosine, PD-1, CTLA-4, and TIGIT) and induced tumor growth inhibition in 2 types of syngeneic mouse models.
    ASP1570 shows antitumor effect depends on CD8+ cytotoxic T-cell activation.

    Physicochemical Properties

    M.Wt 554.59
    Formula C27H25F3N6O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-N-(2-(3-(aminomethyl)piperidin-1-yl)-4-phenoxy-3-(trifluoromethyl)phenyl)-2-(pyridazin-4-yl)thiazole-4-carboxamide

    References

    1. Ikeda O, et al. Mol Cancer Ther. 2025 Mar 26. doi: 10.1158/1535-7163.MCT-23-0108.

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