ASP1570 | DGKζ inhibitor | Probechem Biochemicals

Chemical Structure : ASP1570

ASP1570 (ASP-1570)

Catalog No.: PC-24317Not For Human Use, Lab Use Only.

ASP1570 is a potent, selective diacylglycerol kinase ζ (DGK zeta, DGKζ) inhibitor.

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Biological Activity

ASP1570 is a potent, selective diacylglycerol kinase ζ (DGK zeta, DGKζ) inhibitor.
ASP1570 enhanced T-cell activation with increased diacylglycerol downstream signaling and released anergic T cells from their hyporesponsive state.
ASP1570 restored T-cell functions suppressed by multiple immunosuppressive signals (TGF-β, PGE2, adenosine, PD-1, CTLA-4, and TIGIT) and induced tumor growth inhibition in 2 types of syngeneic mouse models.
ASP1570 shows antitumor effect depends on CD8+ cytotoxic T-cell activation.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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ASP1570 (ASP-1570)

Biological Activity

Physicochemical Properties

References

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