Chemical Structure : ASP1570
Catalog No.: PC-24317Not For Human Use, Lab Use Only.
ASP1570 (Alcudacigib) is a potent, selective diacylglycerol kinase ζ (DGK zeta, DGKζ) inhibitor.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ASP1570 (Alcudacigib) is a potent, selective diacylglycerol kinase ζ (DGK zeta, DGKζ) inhibitor.
ASP1570 enhanced T-cell activation with increased diacylglycerol downstream signaling and released anergic T cells from their hyporesponsive state.
ASP1570 restored T-cell functions suppressed by multiple immunosuppressive signals (TGF-β, PGE2, adenosine, PD-1, CTLA-4, and TIGIT) and induced tumor growth inhibition in 2 types of syngeneic mouse models.
ASP1570 shows antitumor effect depends on CD8+ cytotoxic T-cell activation.
M.Wt | 554.59 | |
Formula | C27H25F3N6O2S | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Ikeda O, et al. Mol Cancer Ther. 2025 Mar 26. doi: 10.1158/1535-7163.MCT-23-0108.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright