| Cat. No. |
Product Name |
Information |
| PC-24989 |
AU3-14
CDK4/6 inhibitor
|
Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3 nM. |
| PC-24530 |
Tagtociclib hydrate
CDK2 inhibitor
|
Tagtociclib hydrate (PF-07104091 hydrate, Tegtociclib hydrate) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers. |
| PC-24325 |
SNX631-6
CDK8/19 inhibitor
|
SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively. |
| PC-23995 |
BLU-222
CDK2 inhibitor
|
Cirtociclib (BLU-222) is a potent, highly selective, ATP-competitive CDK2 inhibitor with IC50 of 2.6 nM (CDK2/cyclinE1) with strong selectivity (>200-fold) over CDK family members (1/4/6/7/9). |
| PC-23058 |
BPI-16350
CDK4/6 inhibitor
|
BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM). |
| PC-22380 |
CDK9 inhibitor VC-1
CDK9 inhibitor
|
CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5. |
| PC-22118 |
AZD8421
CDK2 inhibitor
|
AZD8421 (AZD-8421) is a potent, highly selective CDK2 inhibitor with IC50 of 9 nM, >300-fold selectivity over CDK9. |
| PC-21562 |
GFH009
CDK9 inhibitor
|
GFH009 is a potent, highly selective CDK9 inhibitor with IC50 of 9 nM against CDK9/Cyclin T1 complex, blocks RNAP2-mediated transcription maturation. |
| PC-21500 |
INX-315
CDK2 inhibitor
|
INX-315 (INX315) is a highly potent, selective CDK2 inhibitor with IC50 of 0.6 and 2.5 nM for CDK2/cyclin E1 and CDK2/cyclin A2 respectively, shows high selectivity over other CDK family members. |
| PC-21462 |
CDDD11-8
CDK9/FLT3-ITD inhibitor
|
CDDD11-8 is a potent, selective, orally bioavailable CDK9 inhibitor with Ki of 8 nM, shows >50-fold selectivity over other CDKs, also inhibits FLT3-ITD with Ki of 13 nM. |
| PC-21140 |
Cyclin K degrader DS17
cyclin K degarder
|
Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM. |
| PC-21090 |
RGB-286199
CDK inhibitor
|
RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo. |
