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Cat. No. Product Name Information
PC-24989

AU3-14

CDK4/6 inhibitor

Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3  nM.
PC-24530

Tagtociclib hydrate

CDK2 inhibitor

Tagtociclib hydrate (PF-07104091 hydrate, Tegtociclib hydrate) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers.
PC-24325

SNX631-6

CDK8/19 inhibitor

SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively.
PC-23995

BLU-222

CDK2 inhibitor

Cirtociclib (BLU-222) is a potent, highly selective, ATP-competitive CDK2 inhibitor with IC50 of 2.6 nM (CDK2/cyclinE1) with strong selectivity (>200-fold) over CDK family members (1/4/6/7/9).
PC-23058

BPI-16350

CDK4/6 inhibitor

BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM).
PC-22380

CDK9 inhibitor VC-1

CDK9 inhibitor

CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.
PC-22118

AZD8421

CDK2 inhibitor

AZD8421 (AZD-8421) is a potent, highly selective CDK2 inhibitor with IC50 of 9 nM, >300-fold selectivity over CDK9.
PC-21562

GFH009

CDK9 inhibitor

GFH009 is a potent, highly selective CDK9 inhibitor with IC50 of 9 nM against CDK9/Cyclin T1 complex, blocks RNAP2-mediated transcription maturation.
PC-21500

INX-315

CDK2 inhibitor

INX-315 (INX315) is a highly potent, selective CDK2 inhibitor with IC50 of 0.6 and 2.5 nM for CDK2/cyclin E1 and CDK2/cyclin A2 respectively, shows high selectivity over other CDK family members.
PC-21462

CDDD11-8

CDK9/FLT3-ITD inhibitor

CDDD11-8 is a potent, selective, orally bioavailable CDK9 inhibitor with Ki of 8 nM, shows >50-fold selectivity over other CDKs, also inhibits FLT3-ITD with Ki of 13 nM.
PC-21140

Cyclin K degrader DS17

cyclin K degarder

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM.
PC-21090

RGB-286199

CDK inhibitor

RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.

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