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Cat. No. Product Name Information
PC-22380

CDK9 inhibitor VC-1

CDK9 inhibitor

CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.
PC-21500

INX-315

CDK2 inhibitor

INX-315 (INX315) is a highly potent, selective CDK2 inhibitor with IC50 of 0.6 and 2.5 nM for CDK2/cyclin E1 and CDK2/cyclin A2 respectively, shows high selectivity over other CDK family members.
PC-21462

CDDD11-8

CDK9/FLT3-ITD inhibitor

CDDD11-8 is a potent, selective, orally bioavailable CDK9 inhibitor with Ki of 8 nM, shows >50-fold selectivity over other CDKs, also inhibits FLT3-ITD with Ki of 13 nM.
PC-21140

Cyclin K degrader DS17

cyclin K degarder

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM.
PC-21090

RGB-286199

CDK inhibitor

RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.
PC-21089

RGB-286638

CDK inhibitor

RGB-286638 is a small-molecule multi-targeted cyclin-dependent kinase (CDK) inhibitor with IC50 of 1-5 nM for cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5.
PC-21088

LDC000067

CDK9 inhibitor

LDC000067 (LDC067) is a highly specific inhibitor of CDK9 with IC50 of 44 nM (CDK9-Cyclin T1), highly selective over other CDKs in the range of 55-fold (CDK2) to over 230-fold (CDK6 and CDK7).
PC-21051

SW394703

cyclin K degrader

SW394703 is a novel DDB1-dependent molecular glue degrader for cyclin K, SW394703 is toxic to HCT116 cells (IC50=1.2 uM).
PC-20880

CAF-382

CDKL5 inhibitor

CAF-382 (SGC-CAF382-1) is a potent, specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) with IC50 of 11 nM in NanoBRET assays, shows no activity against GSK3β.
PC-20566

Apcin-A

APC inhibitor, Cdc20 inhibitor

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates.
PC-20494

Cdk5i peptide

Cdk5/p25 inhibitor

Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.
PC-20345

Cdc25A inhibitor 7h

Cdc25A inhibitor

Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA.

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