Cyclin-dependent Kinase (CDK) compound (inhibitors, antagonists)-ProbeChem.com

Request The Product List ofCyclin-dependent Kinase (CDK) Cyclin-dependent Kinase (CDK)

Cat. No.	Product Name	Information
PC-21053	HQ461 cyclin K degrader	HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM.
PC-20887	CDK2 inhibitor 5 CDK2 inhibitor	CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1.
PC-20691	NCGC00131308 IQGAP1-Cdc42 inhibitor	NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays.
PC-49786	MER-128 CDK20 inhibitor	MER-128 is a potent, selective CDK20 inhibitor with IC50 of 2 nM.
PC-49698	EF-4-177 CDK2 inhibitor	EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM. EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding.
PC-38600	GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2 inhibitor	GSK-3/CDK5/CDK2-IN-1 is an inhibitor of CDK5, CDK2 and GSK-3, inhibits the phosphorylation of Cdk5 peptide substrate phosphorylation with IC50 of <50 uM.

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