| Cat. No. |
Product Name |
Information |
| PC-21922 |
LDC3140
CDK7 inhibitor
|
LDC3140 is a potent, selective CDK7 inhibitor with IC50 of <5 nM, >500-fold selective over CDK1/2/4/6/9. |
| PC-21886 |
CVT-313
CDK2 inhibitor
|
CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E. |
| PC-21703 |
CP681301
CDK5 inhibitor
|
CP681301 is a potent, highly specific CDK5 inhibitor, completely inhibits both CDK5-P35 and CDK5-P25 at 1 uM. |
| PC-21681 |
XPW1
CDK9 inhibitor
|
XPW1 is a potent and selective CDK9 inhibitor with excellent anti-ccRCC activity and low toxicity. |
| PC-21527 |
TMX-2039
pan CDK inhibitor
|
TMX-2039 is a pan-CDK inhibitor with low nanomolar enzymatic IC50s (0.5-50 nM) for both cell cycle CDKs (CDK1, CDK2, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). |
| PC-20887 |
CDK2 inhibitor 5
CDK2 inhibitor
|
CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1. |
| PC-49786 |
MER-128
CDK20 inhibitor
|
MER-128 is a potent, selective CDK20 inhibitor with IC50 of 2 nM. |
| PC-49698 |
EF-4-177
CDK2 inhibitor
|
EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM.
EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding. |
| PC-38600 |
GSK-3/CDK5/CDK2-IN-1
GSK-3/CDK5/CDK2 inhibitor
|
GSK-3/CDK5/CDK2-IN-1 is an inhibitor of CDK5, CDK2 and GSK-3, inhibits the phosphorylation of Cdk5 peptide substrate phosphorylation with IC50 of <50 uM. |
