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Chemical Structure : Senexin B
CAS No.: 1449228-40-3
Catalog No.: PC-42425Not For Human Use, Lab Use Only.
Senexin B (SNX2-1-165) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Senexin B (SNX2-1-165) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM.
Senexin B (SNX2-1-165) exhibits selectivity for CDK8 and CDK19 with Kd of 140 nM and 80 nM, respectively.
Senexin B (SNX2-1-165) significantly suppresses tumor growth in ER-positive breast cancer xenografts.
| M.Wt | 450.53 | |
| Formula | C27H26N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-((2-(6-(4-Methylpiperazine-1-carbonyl)naphthalen-2-yl)ethyl)amino)quinazoline-6-carbonitrile |
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1. Donald C. Porter, et al. Abstract PR08: Targeting tumor microenvironment with selective small-molecule inhibitors of CDK8/19.
2. Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer. Publication number: WO2013116786 A1.
3. McDermott MS, et al. Oncotarget. 2017 Feb 21;8(8):12558-12575.
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