| Cat. No. |
Product Name |
Information |
| PC-22380 |
CDK9 inhibitor VC-1
CDK9 inhibitor
|
CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5. |
| PC-21140 |
Cyclin K degrader DS17
cyclin K degarder
|
Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM. |
| PC-21051 |
SW394703
cyclin K degrader
|
SW394703 is a novel DDB1-dependent molecular glue degrader for cyclin K, SW394703 is toxic to HCT116 cells (IC50=1.2 uM). |
| PC-20880 |
CAF-382
CDKL5 inhibitor
|
CAF-382 (SGC-CAF382-1) is a potent, specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) with IC50 of 11 nM in NanoBRET assays, shows no activity against GSK3β. |
| PC-20566 |
Apcin-A
APC inhibitor, Cdc20 inhibitor
|
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. |
| PC-20316 |
LDC4297
CDK7 inhibitor
|
LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM). |
| PC-20219 |
CDK8 inhibitor 32
CDK8 inhibitor
|
CDK8 inhibitor 32 is a potent selective CDK8 inhibitor with IC50 of 1.5 nM, reduces phosphorylation of the known CDK8 substrate STAT1 in a manner identical to a CDK8 knockout clone. |
| PC-49792 |
SGC-CDKL5/GSK3-1
CDKL5/GSK3 inhibitor
|
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively. |
| PC-49789 |
RGB-286147
CDK inhibitor
|
RGB-286147 (RGB 286147) is a proteome-wide CDK/CRK-specific kinase inhibitor with IC50 of 48 and 15 nM for CDK1/CycB and CDK2/CycE, respectively. |
| PC-49785 |
ISM042-2-048
CDK20 inhibitor
|
ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM. |
| PC-49575 |
PF-07220060
CDK4 inhibitor
|
PF-07220060 (CDK4/6-IN-6) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3). |
| PC-49485 |
KB-0742 dihydrochloride
CDK9 inhibitor
|
KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition). |
