| Cat. No. |
Product Name |
Information |
| PC-28564 |
INCB127443
CDK2 inhibitor
|
INCB127443 is a potent, selective and orally bioavailable CDK2 inhibitor with IC50 of 0.99 nM (CDK2/cyclin E1), 316-fold selective over CDK1. |
| PC-28533 |
OKI-1546
CDK12/13 inhibitor
|
OKI-1546 is a potent, selective, covalent and orally bioavailable CDK12/13 inhibitor with IC50 of 15 nM (CDK12), shows 649-, 81-, 11-, and 64-fold selective over CDKs 1, 2, 7, and 9, respectively. |
| PC-28201 |
JH-XVI-178
CDK8/19 inhibitor
|
JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 with IC50 of 1/2 nM respectively. |
| PC-27703 |
UOM-005636
Cyclin K degrader
|
UOM-005636 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 85 nM in OCI-AML5 cells, mediates cyclin K degradation through DDB1 bridging the CRL4 complex. |
| PC-27702 |
Cyclin K MGD S656
Cyclin K degrader
|
Cyclin K MGD S656 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 743 nM in OCI-AML5 cells, mediates cyclin K degradation through the cullin RING ubiquitin ligase complex. |
| PC-27634 |
ZJC-11
CDK7 inhibitor
|
ZJC-11 is a potent, selective and covalent cyclin-dependent kinase 7 (CDK7) inhibitor with IC50 of 5.4 nM, has >100-fold selectivity over CDK1/2/9. |
| PC-27510 |
Tudociclib
CDK2 inhibitor
|
Tudociclib (INCB123667) is a potent and selective, orally available small molecule inhibitor of CDK2 with IC50 of <20 nM, is inactive against CDK1, CDK4, CDK6, CDK7, and CDK9. |
| PC-27409 |
CT7439
CDK12/13 inhibitor, Cyclin K degrader
|
CT7439 (CT-7439) is a potent, selective and oral cyclin-dependent kinases CDK12/CDK13 inhibitor and monovalent glue degrader of cyclin K (CCNK), inhibites OV-90 cell growth with IC50 of 4.4 nM. |
| PC-26877 |
CDK17 inhibitor DU12
CDK17 inhibitor
|
DU12 is a potent small molecule CDK17 inhibitor with IC50 of 0.76 uM against recombinant CDK17 kinase, inhibits the proliferation, colony formation, migration, and invasion of SKOV3 and A2780 ovarian cancer cells with IC50 of 2.83 uM and 2.65 uM. |
| PC-26764 |
A09-003
CDK9 inhibitor
|
A09-003 is a potent inhibitor of cyclin-dependent kinase-9 (CDK9) with IC50 of 16 nM. |
| PC-26376 |
CTX-439
CDK12 inhibitor
|
CTX-439 is a potent, selective, orally bioavailable, ATP-competitive CDK12/13 inhibitor with IC50 of 3.1/ 9.2 nM towards CDK12/Cyclin K and CDK13/Cyclin K, respectively, in cell-free assays. |
| PC-26363 |
Vustanaciclib
CDK2/4/6 inhibitor
|
Vustanaciclib (GDC-4198, RGT-419B) is a potent CDK2/4/6 inhibitor. |
