| Cat. No. |
Product Name |
Information |
| PC-21527 |
TMX-2039
pan CDK inhibitor
|
TMX-2039 is a pan-CDK inhibitor with low nanomolar enzymatic IC50s (0.5-50 nM) for both cell cycle CDKs (CDK1, CDK2, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). |
| PC-21053 |
HQ461
cyclin K degrader
|
HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM. |
| PC-20887 |
CDK2 inhibitor 5
CDK2 inhibitor
|
CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1. |
| PC-20691 |
NCGC00131308
IQGAP1-Cdc42 inhibitor
|
NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays. |
| PC-20589 |
Abemaciclib
CDK4/6 inhibitor
|
Abemaciclib (LY2835219) is a potent, selective and competitive ATP CDK4/6 inhibitor with Ki values of 0.6 and 2.4 nM for CDK4/cyclin D1 and CDK6/cyclin D1, respectively. |
| PC-49787 |
BMS-357075
pan CDK inhibitor
|
BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM. |
| PC-49786 |
MER-128
CDK20 inhibitor
|
MER-128 is a potent, selective CDK20 inhibitor with IC50 of 2 nM. |
| PC-49698 |
EF-4-177
CDK2 inhibitor
|
EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM.
EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding. |
| PC-38600 |
GSK-3/CDK5/CDK2-IN-1
GSK-3/CDK5/CDK2 inhibitor
|
GSK-3/CDK5/CDK2-IN-1 is an inhibitor of CDK5, CDK2 and GSK-3, inhibits the phosphorylation of Cdk5 peptide substrate phosphorylation with IC50 of <50 uM. |
