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Chemical Structure : CDK-TCIP2
Catalog No.: PC-23151Not For Human Use, Lab Use Only.
CDK-TCIP2 is a bivalent molecule linking CDK9 inhibitor SNS-032 to BCL6 ligand BI3812, activates BCL6-regulated transcription, potently and specifically kills BCL6-overexpressing cells with EC50 of 0.9 nM for SUDHL5 cells.
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CDK-TCIP2 is a bivalent molecule linking CDK9 inhibitor SNS-032 to BCL6 ligand BI3812, activates BCL6-regulated transcription, potently and specifically kills BCL6-overexpressing cells with EC50 of 0.9 nM for SUDHL5 cells.
CDK-TCIP2 exhibits improved metabolic stability and higher concentrations in blood than CDK-TCIP1 (Cat# PC-23150) after intraperitoneal dosing, permitting its use in vivo.
CDK-TCIP2 (10 mg/kg once daily, 5 mg/kg twice daily) specifically suppresses the proliferation of GC B cells in a mouse immunization model.
| M.Wt | 1087.75 | |
| Formula | C52H67ClN12O8S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarott RC, et al. Science. 2024 Oct 4;386(6717):eadl5361.
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