| Cat. No. |
Product Name |
Information |
| PC-20390 |
EDG-5506
Myosin inhibitor
|
EDG-5506 (Sevasemten) is a potent, selective, orally active inhibitor of fast skeletal muscle myosin, inhibits fast myofibril ATPase from rabbit psoas muscle with IC50 of 0.2 uM. |
| PC-72702 |
MT-134
SkMII inhibitor
|
MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members. |
| PC-38077 |
Aficamten
Cardiac myosin inhibitor
|
Aficamten (CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy. |
| PC-36046 |
Myokinasib
MLCK1 inhibitor
|
Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex. |
| PC-63125 |
BHC
Myosin inhibitor
|
BHC (Myosin inhibitor BHC) is a small-molecule screen of skeletal muscle myosin inhibitor that suppresses movements without affecting membrane currents. |
| PC-62887 |
ML-9 hydrochloride
MLCK inhibitor
|
ML-9 hydrochloride is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines. |
| PC-60047 |
Mavacamten
Myosin inhibitor
|
Mavacamten (SAR-439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain. |
| PC-45036 |
BTS
myosin II ATPase inhibitor
|
BTS is a highly specific myosin II ATPase inhibitor, inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility. |
| PC-22762 |
CK-586
Cardiac myosin inhibitor
|
CK-4021586 (CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1. |
| PC-22347 |
Blebbistatin
Myosin II inhibitor
|
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. |
| PC-22342 |
Divertin
MLCK1 inhibitor
|
Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo. |
| PC-21413 |
Myosin inhibitor F10
Cardiac-myosin inhibitor
|
Cardiac-myosin inhibitor F10 is a cardiac-myosin specific and allosteric inhibitor with IC50 of 23 uM on actomyosin ATPase activity. |
