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Cat. No. Product Name Information
PC-20390

EDG-5506

Myosin inhibitor

EDG-5506 (Sevasemten) is a potent, selective, orally active inhibitor of fast skeletal muscle myosin, inhibits fast myofibril ATPase from rabbit psoas muscle with IC50 of 0.2 uM.
PC-72702

MT-134

SkMII inhibitor

MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members.
PC-38077

Aficamten

Cardiac myosin inhibitor

Aficamten (CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy.
PC-36046

Myokinasib

MLCK1 inhibitor

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex.
PC-63125

BHC

Myosin inhibitor

BHC (Myosin inhibitor BHC) is a small-molecule screen of skeletal muscle myosin inhibitor that suppresses movements without affecting membrane currents.
PC-62887

ML-9 hydrochloride

MLCK inhibitor

ML-9 hydrochloride is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.
PC-60047

Mavacamten

Myosin inhibitor

Mavacamten (SAR-439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain.
PC-45036

BTS

myosin II ATPase inhibitor

BTS is a highly specific myosin II ATPase inhibitor, inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility.
PC-22762

CK-586

Cardiac myosin inhibitor

CK-4021586 (CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1.
PC-22347

Blebbistatin

Myosin II inhibitor

Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function.
PC-22342

Divertin

MLCK1 inhibitor

Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo.
PC-21413

Myosin inhibitor F10

Cardiac-myosin inhibitor

Cardiac-myosin inhibitor F10 is a cardiac-myosin specific and allosteric inhibitor with IC50 of 23 uM on actomyosin ATPase activity.

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