| Cat. No. |
Product Name |
Information |
| PC-38077 |
Aficamten
Cardiac myosin inhibitor
|
Aficamten (CK-3773274, CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy. |
| PC-36091 |
Danicamtiv
Cardiac myosin activator
|
Danicamtiv (MYK-491) is a positive inotropic agent and selective allosteric activator of cardiac myosin, increases cardiac systolic function and preserves mechanical efficiency. |
| PC-36046 |
Myokinasib
MLCK1 inhibitor
|
Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex. |
| PC-35924 |
ATM-3507
Tropomyosin inhibitor
|
ATM-3507 (ATM3507) is a small molecule inhibitor of Tpm3.1 tropomyosin isoform, disrupts Tpm3.1-containing microfilaments in SK-N-SH cells at 5 uM. |
| PC-63125 |
BHC
Myosin inhibitor
|
BHC (Myosin inhibitor BHC) is a small-molecule screen of skeletal muscle myosin inhibitor that suppresses movements without affecting membrane currents. |
| PC-62887 |
ML-9
MLCK inhibitor
|
ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines. |
| PC-60047 |
Mavacamten
Cardiac myosin inhibitor
|
Mavacamten (SAR439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain, with IC50 of 490 and 711 nM for bovine cardiac and human cardiac myosin, respectively. |
| PC-45036 |
BTS
myosin II ATPase inhibitor
|
BTS is a highly specific myosin II ATPase inhibitor, inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility. |
| PC-28306 |
RLC-1
Cardiac myosin inhibitor
|
RLC-1 is a specific cardiac myosin inhibitor that depends on the presence of a myosin regulatory light chain (RLC), inhibits ATPase in bovine cardiac heavy meromyosin (HMM), but not when RLC is removed. |
| PC-28302 |
EDG-7499
Cardiac sarcomere modulator, Myofibril ATPase inhibitor
|
EDG-7499 a systolic-selective cardiac sarcomere modulator (s-CSM), modulates myosin ATPase indirectly via the myosin RLC. |
| PC-26090 |
CK-571
Smooth muscle myosin inhibitor
|
CK-571 (CK-2018571) is a potent and selective inhibitor of Smooth muscle myosin-2 (SMM) with IC50 of 86 nM. |
| PC-23469 |
Calmodulin inhibitor W-7
Calmodulin antagonist
|
W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively. |
