| Cat. No. |
Product Name |
Information |
| PC-45036 |
BTS
myosin II ATPase inhibitor
|
BTS is a highly specific myosin II ATPase inhibitor, inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility. |
| PC-24900 |
MT-110
Non-muscle myosin II inhibitor
|
MT-110 is a potent, selective, brain penetrant non-muscle myosin II (NMII) inhibitor with EC50 of 0.68 uM in cytokinesis assays, >70-fold selectivity over cardiac muscle myosin II (CMII). |
| PC-24862 |
MT-125
non-muscle myosin II inhibitor
|
MT-125 is a specific, brain penetrant small-molecule inhibitor of non-muscle myosin IIA and IIB (NMIIA and IIB) with Ki of 2.7 uM (NMIIA) and EC50 of 1.7 uM (NMIIB). |
| PC-24122 |
Delocamten
Cardiac myosin inhibitor
|
Delocamten is a potent selective cardiac myosin inhibitor with potential treatment of hypertrophic cardiomyopathy (HCM). |
| PC-23469 |
Calmodulin inhibitor W-7
Calmodulin antagonist
|
W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively. |
| PC-23211 |
MT-228
non-muscle myosin II inhibitor
|
MT-228 is a potent, selective, first-in-class non-muscle myosin II (NMII) inhibitor with Ki of 1.5 uM and cytokinesis EC50 of 1.0 uM, 17-fold selectivity for NMII over cardiac myosin II (CMII). |
| PC-23164 |
Myokinasib-II
MLCK inhibitor
|
Myokinasib-II is a potent and highly selective myosin light-chain kinase (MLCK) chemical probe inhibitor with IC50 of 4.4 uM for MLCK-1. |
| PC-23162 |
ML-9 free base
MLCK inhibitor
|
ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines. |
| PC-22342 |
Divertin
MLCK1 inhibitor
|
Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo. |
| PC-21413 |
Myosin inhibitor F10
Cardiac-myosin inhibitor
|
Cardiac-myosin inhibitor F10 is a cardiac-myosin specific and allosteric inhibitor with IC50 of 23 uM on actomyosin ATPase activity. |
| PC-43535 |
Blebbistatin S enantiomer
|
Blebbistatin S enantiomer ((S)-(-)-Blebbistatin) is the S enantiomer of blebbistatin, which is a potent and selective myosin II inhibitor with IC50 of 0.5-5 uM. |
