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Chemical Structure : ATM-3507
CAS No.: 1861449-70-8
Catalog No.: PC-35924Not For Human Use, Lab Use Only.
ATM-3507 (ATM3507) is a small molecule inhibitor of Tpm3.1 tropomyosin isoform, disrupts Tpm3.1-containing microfilaments in SK-N-SH cells at 5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ATM-3507 (ATM3507) is a small molecule inhibitor of Tpm3.1 tropomyosin isoform, disrupts Tpm3.1-containing microfilaments in SK-N-SH cells at 5 uM.
ATM-3507 shows cancer cell cytotoxicity comparable with the first-in-class tool compound TR100.
ATM-3507 also shows a strong synergistic effect when TR100 or ATM-3507 were combined with antimicrotubule agents in both in vitro and in vivo neuroblastoma models.
| M.Wt | 611.806 | |
| Formula | C37H46FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3-((2,3-dimethyl-1-(3-(4-methylpiperazin-1-yl)propyl)-1H-indol-5-yl)oxy)phenyl)(4-(4-fluorophenethyl)piperazin-1-yl)methanone |
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1. Currier MA, et al. Mol Cancer Ther. 2017 Aug;16(8):1555-1565.
2. Mitchell CB, et al. Cytoskeleton (Hoboken). 2018 Jul;75(7):307-317.
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