| Cat. No. |
Product Name |
Information |
| PC-28301 |
EDG-7500
Cardiac sarcomere modulator, Myofibril ATPase inhibitor
|
EDG-7500 is a diastolic-selective cardiac sarcomere modulator (d-CSM) that preferentially inhibits cardiac myofibril ATPase activity with EC25 value of 3.0 nM at diastolic calcium levels, with limited activity at systolic calcium levels (EC25>100 uM). |
| PC-24900 |
MT-110
Non-muscle myosin II inhibitor
|
MT-110 is a potent, selective, brain penetrant non-muscle myosin II (NMII) inhibitor with EC50 of 0.68 uM in cytokinesis assays, >70-fold selectivity over cardiac muscle myosin II (CMII). |
| PC-24862 |
MT-125
non-muscle myosin II inhibitor
|
MT-125 is a specific, brain penetrant small-molecule inhibitor of non-muscle myosin IIA and IIB (NMIIA and IIB) with Ki of 2.7 uM (NMIIA) and EC50 of 1.7 uM (NMIIB). |
| PC-24122 |
Delocamten
Cardiac myosin inhibitor
|
Delocamten (MYK-224, BMS-986435) is a potent selective cardiac myosin inhibitor with potential treatment of hypertrophic cardiomyopathy (HCM). |
| PC-23405 |
Adhibin
class-IX myosins inhibitor
|
Adhibin is a selective and allosteric inhibitor of RhoGAP class-IX myosins that abrogates ATPase and motor function, suppressing RhoGTPase-mediated modes of cancer cell metastasis. |
| PC-23211 |
MT-228
non-muscle myosin II inhibitor
|
MT-228 is a potent, selective, first-in-class non-muscle myosin II (NMII) inhibitor with Ki of 1.5 uM and cytokinesis EC50 of 1.0 uM, 17-fold selectivity for NMII over cardiac myosin II (CMII). |
| PC-23161 |
ML-7 hydrochloride
MLCK inhibitor
|
ML-7 hydrochloride is a potent, specific myosin light chain kinase (MLCK) inhibitor with IC50 of 300 nM, also inhibits YAP/TAZ. |
| PC-22762 |
Ulacamten
Cardiac myosin inhibitor
|
Ulacamten (CK-4021586, CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1. |
| PC-22347 |
Blebbistatin
Non-muscle myosin II inhibitor
|
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. |
| PC-22342 |
Divertin
MLCK1 inhibitor
|
Divertin (NSC55937, Tetraformaltrisazine) is a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo. |
| PC-20390 |
Sevasemten
Myosin inhibitor
|
Sevasemten (EDG-5506) is a potent, selective, orally active inhibitor of fast skeletal muscle myosin, inhibits fast myofibril ATPase from rabbit psoas muscle with IC50 of 0.2 uM. |
| PC-72702 |
MT-134
SkMII inhibitor
|
MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members. |
