| Cat. No. |
Product Name |
Information |
| PC-20390 |
EDG-5506
Myosin inhibitor
|
EDG-5506 (Sevasemten) is a potent, selective, orally active inhibitor of fast skeletal muscle myosin, inhibits fast myofibril ATPase from rabbit psoas muscle with IC50 of 0.2 uM. |
| PC-72702 |
MT-134
SkMII inhibitor
|
MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members. |
| PC-38077 |
Aficamten
Cardiac myosin inhibitor
|
Aficamten (CK-3773274, CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy. |
| PC-36091 |
Danicamtiv
Cardiac myosin activator
|
Danicamtiv (MYK-491) is a positive inotropic agent and selective allosteric activator of cardiac myosin, increases cardiac systolic function and preserves mechanical efficiency. |
| PC-36046 |
Myokinasib
MLCK1 inhibitor
|
Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex. |
| PC-63125 |
BHC
Myosin inhibitor
|
BHC (Myosin inhibitor BHC) is a small-molecule screen of skeletal muscle myosin inhibitor that suppresses movements without affecting membrane currents. |
| PC-62887 |
ML-9
MLCK inhibitor
|
ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines. |
| PC-60047 |
Mavacamten
Cardiac myosin inhibitor
|
Mavacamten (SAR439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain, with IC50 of 490 and 711 nM for bovine cardiac and human cardiac myosin, respectively. |
| PC-45036 |
BTS
myosin II ATPase inhibitor
|
BTS is a highly specific myosin II ATPase inhibitor, inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility. |
| PC-23469 |
Calmodulin inhibitor W-7
Calmodulin antagonist
|
W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively. |
| PC-23405 |
Adhibin
class-IX myosins inhibitor
|
Adhibin is a selective and allosteric inhibitor of RhoGAP class-IX myosins that abrogates ATPase and motor function, suppressing RhoGTPase-mediated modes of cancer cell metastasis. |
| PC-23211 |
MT-228
non-muscle myosin II inhibitor
|
MT-228 is a potent, selective, first-in-class non-muscle myosin II (NMII) inhibitor with Ki of 1.5 uM and cytokinesis EC50 of 1.0 uM, 17-fold selectivity for NMII over cardiac myosin II (CMII). |
