Divertin | MLCK1 inhibitor | Probechem Biochemicals

Chemical Structure : Divertin

Divertin (NSC55937, Tetraformaltrisazine)

Catalog No.: PC-22342Not For Human Use, Lab Use Only.

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Biological Activity

Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo.
Divertin restore barrier function in spontaneous colitis, and attenuate experimental, immune-mediated colitis.
Divertin reverses TNF-induced MLC phosphorylation and barrier loss in vitro.
Divertin prevents acute TNF-induced MLC phosphorylation, barrier loss, and diarrhea in vivo.
Divertin prevents TNF-induced MLCK1 trafficking, MLC phosphorylation, and tight junction reorganization in human jejunal mucosae ex vivo.
Divertin corrects intestinal permeability defects and limits progression of experimental inflammatory bowel disease.

Physicochemical Properties

M.Wt	144.18
Formula	C4H12N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,3,4,6,7,8,9-octahydro-[1,2,4,5]tetrazino[1,2-a][1,2,4,5]tetrazine

References

1. Tang H, et al. Discov Oncol. 2024 May 12;15(1):159.

2. Graham WV, et al. Nat Med. 2019 Apr;25(4):690-700.

Divertin (NSC55937, Tetraformaltrisazine)

Biological Activity

Physicochemical Properties

References

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