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Chemical Structure : Divertin
Catalog No.: PC-22342Not For Human Use, Lab Use Only.
Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo.
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Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo.
Divertin restore barrier function in spontaneous colitis, and attenuate experimental, immune-mediated colitis.
Divertin reverses TNF-induced MLC phosphorylation and barrier loss in vitro.
Divertin prevents acute TNF-induced MLC phosphorylation, barrier loss, and diarrhea in vivo.
Divertin prevents TNF-induced MLCK1 trafficking, MLC phosphorylation, and tight junction reorganization in human jejunal mucosae ex vivo.
Divertin corrects intestinal permeability defects and limits progression of experimental inflammatory bowel disease.
| M.Wt | 144.18 | |
| Formula | C4H12N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tang H, et al. Discov Oncol. 2024 May 12;15(1):159.
2. Graham WV, et al. Nat Med. 2019 Apr;25(4):690-700.
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