| Cat. No. |
Product Name |
Information |
| PC-25371 |
LAG-3 inhibitor 11
LAG-3 inhibitor
|
LAG-3 inhibitor 11 is a potent, small molecule LAG-3 inhibitor, binds LAG-3 with MST KD of 0.41 uM, demonstrates disruption of the LAG-3/MHC II interaction in a cellular assay with EC50 of 0.31 uM. |
| PC-23564 |
DRI-C21041
CD40-CD40L inhibitor
|
DRI-C21041 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.31 uM in cell-free in vitro binding inhibition assay. |
| PC-23563 |
DRI-C21095
CD40-CD40L inhibitor
|
DRI-C21095 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.17 uM in cell-free in vitro binding inhibition assay. |
| PC-22944 |
ICOS inhibitor 9
ICOS/ICOS-L inhibitor
|
ICOS inhibitor 9 is a small molecule inhibitor of ICOS/ICOS-L interaction with IC50 of 29.38 uM. |
| PC-21817 |
MTX-3937
Siglec-9 inhibitor
|
MTX-3937 is a small-molecule Siglec-9 inhibitor with binding KD of 3.15 uM in BLI assay, inhibits phosphorylation of Siglec-9 and downstream SHP1 and SHP2. |
| PC-21257 |
VISTA inhibitor compound 1
VISTA inhibitor
|
VISTA inhibitor compound 1 is a bifunctional inhibitor targeting VISTA, shows good binding affinity with VISTA (SPR KD=256 nM), induces potent VISTA degradation in HepG2 cells and activates antitumor immunity. |
| PC-21199 |
AG-120-X
ICOS/ICOSL inhibitor
|
AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL. |
| PC-21024 |
TIM-3 inhibitor 38
TIM-3 inhibitor
|
TIM-3 inhibitor 38 is a small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with Ki of 70 nM in FPA competition assays. |
| PC-21023 |
TIM-3 inhibitor A-41
TIM-3 inhibitor
|
TIM-3 inhibitor A-41 is small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with SPR Kd value of 0.61 uM. |
| PC-20828 |
LAG-3 inhibitor SA-15-P
LAG-3 inhibitor
|
LAG-3 inhibitor SA-15-P is a small molecule dual inhibitor of LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 of 4.21 and 6.52 uM, respectively. |
| PC-38590 |
VISTA inhibitor M351-056
VISTA inhibitor
|
VISTA inhibitor M351-056 is a small molecule compound having affinity with VISTA. |
| PC-38588 |
Compound 6809-0223
VISTA inhibitor
|
Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD). |
