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ORS-14

Chemical Structure : ORS-14

CAS No.: 1311892-52-0

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ORS-14 (ORS14)

Catalog No.: PC-28168Not For Human Use, Lab Use Only.

ORS-14 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 85.2 nM, binds LILRB4 extracellular domain.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ORS-14 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 85.2 nM, binds LILRB4 extracellular domain.
ORS-14 restores anti-tumor immune activity across colorectal cancer and AML co-culture systems.
ORS-14 is capable of reversing SCG2-driven immunosuppression and restoring productive immune activity in clinically relevant human tumor co-culture systems. 

Physicochemical Properties

M.Wt 323.36
Formula C17H17N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((2-(3,4-dimethylphenoxy)pyridin-4-yl)methyl)-1H-1,2,3-triazole-4-carboxamide

References

1. Abdel-Rahman SA, et al. Bioorg Med Chem Lett. 2026 Nov;140:130717.

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