| Cat. No. |
Product Name |
Information |
| PC-23624 |
Prostetin-12k
MAP4K inhibitor, MLK3 inhibitor
|
Famlasertib (Prostetin/12k) is a highly potent, blood-brain barrier-penetrant inhibitor of mitogen-activated protein kinase kinase kinase kinase (MAP4K) family with IC50 of 0.3 nM for HGK (MAP4K4) and 23.7 nM for MLK3. |
| PC-23370 |
NDI-101150
HPK1 inhibitor
|
NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with biochemicals IC50 of 0.7 nM and cellular IC50 of 41 nM. |
| PC-21340 |
DS21150768
HPK1/MAP4K1 inhibitor
|
DS21150768 is a potent selective and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with IC50 of 3.27 nM in cell-free HPK1 assays, binds to HPK1 with an affinity constant (KD) of 6.08 nM. |
| PC-20029 |
F389-0746
MAP4K4 inhibitor
|
F389-0746 is a potent, selective and orally active MAP4K4 inhibitor with IC50 of 120.7 nM. |
| PC-49661 |
BAY-405
HPK1/MAP4K1 inhibitor
|
BAY-405 (BAY405) is a potent, selective MAP4K1 (HPK1) inhibitor with IC50 of 6 nM in binding competition assays. |
| PC-38665 |
HPK inhibitor compound 1
HPK1 inhibitor
|
HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1. |
| PC-72305 |
ZYF0033
HPK1/MAP4K1 inhibitor
|
ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 (MAP4K1) with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein. |
| PC-72304 |
GNE-1858
HPK1/MAP4K1 inhibitor
|
GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay. |
| PC-72303 |
A-745
HPK1/MAP4K1 inhibitor
|
A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM. |
| PC-72055 |
HPK1 inhibitor CompK
HPK1/MAP4K1 inhibitor
|
Compound K (HPK1 inhibitor CompK) is a novel, potent, highly selective HPK1 (MAP4K1) kinase inhibitor with IC50 of 2.6 nM, 50-fold selectivity against other members of the MAP4K family. |
| PC-72013 |
HPK1 inhibitor 1
HPK1/MAP4K1 inhibitor
|
HPK1 inhibitor 1 is a highly potent, selective inhibitor of HPK1/MAP4K1 with biochemical IC50 of 0.0465 nM. |
| PC-36139 |
DMX-5804
MAP4K4 inhibitor
|
DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM. |
