| Cat. No. |
Product Name |
Information |
| PC-26106 |
HDM2004
HPK1 inhibitor
|
HDM2004 is a potent, selective and orally bioavailable HPK1 (MAP4K1) inhibitor with IC50 of 1.89 nM, >30-fold selectivity over the closely related kinase GLK. |
| PC-23939 |
AZ3246
HPK1 inhibitor
|
AZ3246 is a potent, highly selective inhibitor of hematopoietic progenitor kinase 1 (HPK1, MAP4K1) with IC50 of <3 nM in ADP-Glo assays, 20-fold more selective over GLK and no activity against LCK. |
| PC-23624 |
Prostetin-12k
MAP4K inhibitor, MLK3 inhibitor
|
Famlasertib (Prostetin/12k) is a highly potent, blood-brain barrier-penetrant inhibitor of mitogen-activated protein kinase kinase kinase kinase (MAP4K) family with IC50 of 0.3 nM for HGK (MAP4K4) and 23.7 nM for MLK3. |
| PC-23589 |
PF-07265028
HPK1 inhibitor
|
PF-07265028 is a potent, selective hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with Ki of <0.05 nM, and cellular IC50 of 17 nM (pSLP76 inhibition). |
| PC-23370 |
NDI-101150
HPK1 inhibitor
|
NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with biochemicals IC50 of 0.7 nM and cellular IC50 of 41 nM. |
| PC-23066 |
BGB-15025
HPK1 inhibitor
|
BGB-15025 is a potent and selective hematopoietic progenitor kinase 1 (HPK1) inhibitor with biochemical IC50 of 1.04 nM. |
| PC-23064 |
GNE-6893
HPK1 inhibitor
|
GNE-6893 is a potent, selective and orally active inhibitor of HPK1 (hematopoietic progenitor kinase 1) with Ki of <0.019 nM, potently inhibits phosphorylation of SLP76 with IC50 of 44 nM in Jurkat cell assay. |
| PC-21340 |
DS21150768
HPK1 inhibitor
|
DS21150768 is a potent selective and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with IC50 of 3.27 nM in cell-free HPK1 assays, binds to HPK1 with an affinity constant (KD) of 6.08 nM. |
| PC-20029 |
F389-0746
MAP4K4 inhibitor
|
F389-0746 is a potent, selective and orally active MAP4K4 inhibitor with IC50 of 120.7 nM. |
| PC-49661 |
BAY-405
HPK1/MAP4K1 inhibitor
|
BAY-405 (BAY405) is a potent, selective MAP4K1 (HPK1) inhibitor with IC50 of 6 nM in binding competition assays. |
| PC-38665 |
HPK inhibitor compound 1
HPK1 inhibitor
|
HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1. |
| PC-72305 |
ZYF0033
HPK1/MAP4K1 inhibitor
|
ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 (MAP4K1) with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein. |
