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PF-07265028

Chemical Structure : PF-07265028

CAS No.: 2736459-09-7

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PF-07265028 (PF07265028)

Catalog No.: PC-23589Not For Human Use, Lab Use Only.

PF-07265028 is a potent, selective hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with Ki of <0.05 nM, and cellular IC50 of 17 nM (pSLP76 inhibition).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-07265028 is a potent, selective hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with Ki of <0.05 nM, and cellular IC50 of 17 nM (pSLP76 inhibition).
PF-07265028 only inhibits at a less than 30-fold window relative to HPK1 for 2 out of 395 kinases (MAP4K5 and TAOK1).
PF-07265028 shows potent functional response in human T cells as measured by induction of IL-2 production with EC50 of 59 nM.

Physicochemical Properties

M.Wt 446.56
Formula C24H30N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[(1R)-1-Aminopropyl]-2-[6-(4-ethyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl]-6-[(2R)-2-methylpyrrolidin-1-yl]-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one

References

1. Gallego RA, et al. J Med Chem. 2024 Dec 9. doi: 10.1021/acs.jmedchem.4c01930.

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