| Cat. No. |
Product Name |
Information |
| PC-49501 |
Compound 3289-8625
Dvl PDZ inhibitor
|
Compound 3289-8625 is a small molecule inhibitor of the PDZ domain of dishevelled (Dvl) with KD of 10.6 uM, competitively inhibits the Wnt signaling. |
| PC-49500 |
NPL-4011
Dvl1-PDZ inhibitor
|
NPL-4011 is a specific small molecule inhibitor of PDZ domain of human Dvl1 (Dvl1-PDZ) with KD vaule of 34.5 uM in NMR titration experiments. |
| PC-73380 |
KY19334
CXXC5-Dvl PPI
|
KY19334 is a specific small molecule inhibitor of CXXC5-Dishevelled (Dvl) protein-protein interaction (PPI), restores the Wnt/β-catenin signalling. |
| PC-63513 |
KY-02061
CXXC5-Dvl PPI
|
KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay. |
| PC-63512 |
KY-02327
CXXC5-Dvl PPI
|
KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog. |
| PC-61785 |
NSC 668036
Dvl1-PDZ inhibitor
|
NSC 668036 is a specific inhibitor of the Dishevelled (Dvl) PDZ domain, extremely weakly binds to PSD-95, PSD95, and PDZ7 domain of GRIP. |
| PC-24368 |
WC593
pan-Dvl inhibitor
|
WC593 is a potent pan-dishevelled (Dvl) inhibitor, blocks Wnt–β-catenin signaling and CRC cell proliferation. |
| PC-24367 |
WC522
Dvl2 inhibitor
|
WC522 is a selective small molecule inhibitor of Dvl2-PDZ-cholesterol interaction, effectively suppresses both Wnt-independent and Wnt-stimulated β-catenin signaling activity in Dvl2-expressing APC-truncated CRC cells. |
| PC-20575 |
BMD4702
Dishevelled inhibitor
|
BMD4702 is a small molecule Dishevelled (Dvl) PDZ domain with binding Kd of 186 nM. |
| PC-20574 |
BMD4722
Dishevelled inhibitor
|
BMD4722 is a highly potent, small-molecule inhibitor of Dvl-CXXC5 interaction with IC50 of 2.59 uM, directly binds to the Dvl PDZ domain (Kd=22.3 uM). |
