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Chemical Structure : Compound 3289-8625
CAS No.: 294891-81-9
Catalog No.: PC-49501Not For Human Use, Lab Use Only.
Compound 3289-8625 is a small molecule inhibitor of the PDZ domain of dishevelled (Dvl) with KD of 10.6 uM, competitively inhibits the Wnt signaling.
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Compound 3289-8625 is a small molecule inhibitor of the PDZ domain of dishevelled (Dvl) with KD of 10.6 uM, competitively inhibits the Wnt signaling.
Compound 3289-8625 (3 uM) inhibits Wnt signaling, effectively reduces luciferase activity by about 2-fold 293 cell line stably transfected with a luciferase reporter.
Compound 3289-8625 is cell-permeable and 3289-8625 (10 uM) blocks Wnt signaling in Xenopus, inhibits Wnt pathway responses in culture and in vivo.
Compound 3289-8625 suppresses cell proliferation and reduces β-catenin level in prostate cancer PC-3 cells, decreases the levels of β-catenin in both cytosolic fraction and membrane fraction.
Compound 3289-8625 sensitized A2780/Taxol cells to paclitaxel.
| M.Wt | 374.40 | |
| Formula | C22H18N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-(2-phenylacetamido)benzamido)benzoic acid |
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1. David Grandy, et al. J Biol Chem. 2009 Jun 12;284(24):16256-16263.
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