| Cat. No. |
Product Name |
Information |
| PC-24036 |
TNG348
USP1 inhibitor
|
TNG348 is a potent, a selective, allosteric and reversible USP1 inhibitor with IC50 of 98.6 nM in AlphaLISA-based measurement of ub-PCNA induction in MDA-MB-436 cells. |
| PC-21881 |
P22077
USP7/USP47 inhibitor
|
P22077 is a selective cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with IC50 of 8.01 uM, also inhibits USP47 with IC50 of 8.47 uM. |
| PC-21796 |
YCH2823
USP7 inhibitor
|
YCH2823 is a potent, selective USP7 inhibitor with IC50 of 49.6 nM, ITC Kd of 117 nM. |
| PC-21610 |
HY041004
JOSD2 inhibitor
|
HY041004 is the first small molecule inhibitor of deubiquitinase Josephin Domain-containing protein 2 (JOSD2) with IC50 of 0.26 uM for JOSD2 catalytic activity inhibition. |
| PC-21573 |
NCI677397
USP24 inhibitor
|
NCI677397 is a specific small molecule inhibitor of USP24, inhibits chemotherapy-induced drug resistance in vitro and in vivo. |
| PC-21561 |
P5091
USP7 inhibitor
|
P5091 is a potent, specific inhibitor of ubiquitin-specific protease 7 (USP7) with IC50 of 4.2 uM, does not inhibit other DUBs or other families of cysteine proteases (EC50> 100 uM). |
| PC-21519 |
MS102
USP2 inhibitor
|
MS102 is a small molecule, orally available USP2 inhibitor with IC50 of 5.46 uM, induces transient degradation of ACE2 protein and inhibits ACE2-dependent coronavirus infection. |
| PC-21498 |
IMP-2373
DUB CNPy Probe
|
IMP-2373 is a highly targeted cyanopyrrolidine (CNPy) probe for pan-DUB to monitor DUB activity in physiologically relevant live cells. |
| PC-21351 |
MTX115325
USP30 inhibitor
|
MTX115325 (MTX325, MTX-325) is a potent, selective, brain-penetrant USP30 inhibitor with IC50 of 12 nM in biochemical fluorescence polarization assays. |
| PC-21098 |
LN5P45
OTUB2 inhibitor
|
LN5P45 is a selective, covalent, irreversible inhibitor of ubiquitin thioesterase OTUB2 with IC50 of 2.3 uM, strongly induces monoubiquitination of OTUB2 on Lys31. |
| PC-20656 |
b-AP15
USP14 inhibitor
|
b-AP15 is a specific inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), inhibits DUB activity in purified 19S proteasomes with IC50 of 2.1 uM. |
| PC-20480 |
Neutral Red
USP4 inhibitor
|
Neutral Red is a nitrogenous pH-indicator that can stains lysosomes red, also is a selective, uncompetitive USP4 inhibitor with IC50 of 50 uM. |
