| Cat. No. |
Product Name |
Information |
| PC-24036 |
TNG348
USP1 inhibitor
|
TNG348 is a potent, a selective, allosteric and reversible USP1 inhibitor with IC50 of 98.6 nM in AlphaLISA-based measurement of ub-PCNA induction in MDA-MB-436 cells. |
| PC-23143 |
IsoLiPro
USP11 inhibitor
|
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination. |
| PC-22877 |
YCH3124
USP7 inhibitor
|
YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25. |
| PC-22313 |
USP10 inhibitor D1
USP10 inhibitor
|
USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay. |
| PC-22260 |
FX1-5303
USP7 inhibitor
|
FX1-5303 is a highly potent, specific ubiquitin-specific protease 7 (USP7) inhibitor with biochemical IC50 of 0.29 nM. |
| PC-21919 |
LLK203
USP2/USP8 inhibitor
|
LLK203 is a potent, dual-targeting USP2/USP8 inhibitor with IC50 of 0.89/0.52 uM, potently inhibits cell proliferation of MCF-7 breast cancer cells with IC50 of 3.4 uM. |
| PC-21918 |
PCR-6236
USP2/USP8 inhibitor
|
PCR-6236 is a potent dual-targeting USP2/USP8 inhibitor with IC50 of <0.1/0.8 uM, respectively. |
| PC-21881 |
P22077
USP7/USP47 inhibitor
|
P22077 is a selective cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with IC50 of 8.01 uM, also inhibits USP47 with IC50 of 8.47 uM. |
| PC-21796 |
YCH2823
USP7 inhibitor
|
YCH2823 is a potent, selective USP7 inhibitor with IC50 of 49.6 nM, ITC Kd of 117 nM. |
| PC-21610 |
HY041004
JOSD2 inhibitor
|
HY041004 is the first small molecule inhibitor of deubiquitinase Josephin Domain-containing protein 2 (JOSD2) with IC50 of 0.26 uM for JOSD2 catalytic activity inhibition. |
| PC-21573 |
NCI677397
USP24 inhibitor
|
NCI677397 (USP24-i) is a specific small molecule inhibitor of USP24, inhibits chemotherapy-induced drug resistance in vitro and in vivo. |
| PC-21561 |
P5091
USP7 inhibitor
|
P5091 is a potent, specific inhibitor of ubiquitin-specific protease 7 (USP7) with IC50 of 4.2 uM, does not inhibit other DUBs or other families of cysteine proteases (EC50> 100 uM). |
